Pentedrone

Source: Wikipedia, the free encyclopedia.
Pentedrone
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • (±)-1-phenyl-2-(methylamino)pentan-1-one
JSmol)
  • O=C(C(CCC)NC)C1=CC=CC=C1
  • InChI=1S/C12H17NO/c1-3-7-11(13-2)12(14)10-8-5-4-6-9-10/h4-6,8-9,11,13H,3,7H2,1-2H3 checkY
  • Key:WLIWIUNEJRETFX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pentedrone (also known as α-methylaminovalerophenone) is a stimulant of the cathinone class that has been sold as a designer drug and has been found since 2010 as an ingredient in a number of "bath salt" mixes sold as legal highs.[3][4][5][6][7][8][9]

Pharmacology

Pentedrone acts as a

norepinephrine-dopamine reuptake inhibitor without causing their release, the same mechanism of action as methylphenidate.[10][11]

Side effects

Pentedrone has been linked to at least one death where it was combined with α-PVP and caused heart failure.[12]

Detection

A forensic standard of pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[13]

Legal status

On January 28, 2014, the DEA listed it, along with nine other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.[14]

Pentedrone is an Anlage II controlled drug in Germany.

As of October 2015 Pentedrone is a controlled substance in China.[15]

Pentedrone is banned in the Czech Republic.[16]

See also

References

  1. ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  2. ^ "Substance Details Pentedrone". Retrieved 2024-01-22.
  3. ^ "EMCDDA Annual Report 2010" (PDF). Archived from the original (PDF) on 2012-03-14. Retrieved 2011-10-15.
  4. ^ Research on Head Shop drugs in Dublin: Part 2
  5. ^ An overview of new psychoactive substances and the outlets supplying them
  6. PMID 22115724
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  13. ^ "Pentedrone". Southern Association of Forensic Scientists. Retrieved 8 September 2015.
  14. ^ "Temporary Placement of 10 Synthetic Cathinones into Schedule I". 28 January 2014. Archived from the original on 17 October 2016. Retrieved 16 February 2014.
  15. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  16. ^ "Látky, o které byl doplněn seznam č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.)" (PDF) (in Czech). Ministerstvo zdravotnictví. Archived from the original (PDF) on 2016-03-09. Retrieved 2016-02-06.