Perindopril/indapamide

Source: Wikipedia, the free encyclopedia.
Perindopril/indapamide
By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only[1]
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
  (verify)

Perindopril/indapamide (marketed as Preterax, Coversyl Plus and Noliprel) is a combination medication which contains perindopril (an ACE inhibitor) and indapamide (a thiazide-like diuretic) both of which are used for the treatment of essential hypertension (high blood pressure).[2]

Medical uses

High blood pressure

Administration

One tablet daily, preferably to be taken in the morning and before a meal.

Elderly: Normal dosage.

contraindicated
.

Contraindications

Absolute contraindications to taking perindopril/indapamide include a known

Quincke's edema linked to previous ACE inhibitor therapy; end-stage kidney disease; serious liver disease; high levels of potassium in the blood; pregnancy; and lactation
.

Relative contraindications to using this medication include combination therapy with

abnormal heart rhythms
.

Side effects

Side effects of perindopril/indapamide may include

congestive heart failure
.

Immunosuppressed patients. Hemodialysis
: risk of anaphylactoid reaction during hemodialysis with polyacrylonitrile membranes. Liver impairment.

Caution is recommended when prescribing perindopril/indapamide to people with electrolyte disorders, diabetes, gout, low blood pressure, or strict sodium-free diets, heart or kidney failure, atherosclerosis, renal artery stenosis, and in elderly people.

Pharmacology

Using a fixed combination of an

vascular endothelium, arteriolocapillary microcirculation
, and the target organs of hypertension.

Drug interactions

Not recommended: combinations with lithium, potassium-sparing diuretics, potassium (salts),

immunosuppressive agents
.

References

  1. ^ "Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 3 April 2024.
  2. ISBN 978-1-118-59256-4
    .
Retrieved from "https://en.wikipedia.org/w/index.php?title=Perindopril/indapamide&oldid=1216994581"