Phenazone

Source: Wikipedia, the free encyclopedia.
Phenazone
Clinical data
Other namesanalgesine, antipyrine
ATC code
Pharmacokinetic data
Elimination half-life12 hours
Identifiers
  • 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
JSmol)
  • O=C1C=C(C)N(C)N1c2ccccc2
  • InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3 checkY
  • Key:VEQOALNAAJBPNY-UHFFFAOYSA-N checkY
  (verify)

Phenazone (

over-the-counter
or prescribed drug.

History

Ludwig Knorr was the first to synthesize phenazone, then called antipyrine, in the early 1880s. Sources disagree on the exact year of discovery, but Knorr patented the chemical in 1883.[3][4][5]: 26–27  Phenazone has an elimination half life of about 12 hours.[6]

Preparation

Phenazone is synthesized

oxidizes
it to pyridazine tetracarboxylic acid.

Adverse effects

Possible adverse effects include:[citation needed]

Research

Phenazone is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.[9]

See also

References

  1. doi:10.1016/S0140-6736(02)13571-9
    .
  2. doi:10.1021/ie50201a027
    . Retrieved 2022-08-11.
  3. PMID 25975100
    .
  4. doi:10.1016/S1366-0071(97)80033-2
    .
  5. ISBN 9783527326693
    .
  6. ^ "Phenazone Concise Prescribing Info". MIMS.
  7. ISBN 8122415652
    .: 226 
  8. ^ "5-Methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one". Chemspider. Retrieved February 24, 2019.
  9. ^ "Antipyrine drugs and health products". sDrugs.com.


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