Phillip Allen Sharp
Phillip Allen Sharp | |
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 Sharp with the Winthrop-Sears Medal in 2007 | |
| Born | June 6, 1944 Falmouth, Kentucky, U.S. |
| Alma mater |
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| Spouse |
Ann Holcombe (m. 1964) |
| Children | 3 |
| Awards |
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| Scientific career | |
| Fields | Biologist |
| Institutions |
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| Doctoral students | |
| Website | web |
| External videos | |
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MIT |
Phillip Allen Sharp (born June 6, 1944) is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence".[2][3][4][5][6][7] He has been selected to receive the 2015 Othmer Gold Medal.[8]
Sharp's current research focuses on small RNAs and other types of
transcription start sites. His laboratory also studies how miRNA gene regulation functions in angiogenesis and cellular stress.[9][10][11][12]
Biography
Sharp was born in Falmouth, Kentucky, the son of Kathrin (Colvin) and Joseph Walter Sharp.[13] He married Ann Holcombe in 1964, and they have three daughters.[14]
Sharp studied at
James D. Watson.[16]
In 1974, he was offered a position at
Unabomber because of his work in genetics, stating that "it would be beneficial to your health to stop your research in genetics."[17]
He is currently MIT Professor of Biology Emeritus and member of the
Institute Professor since 1999.[15] He is also the chair of the advisory board of the MIT Jameel Clinic.[18][19] Sharp co-founded Biogen, Alnylam Pharmaceuticals, and Magen Biosciences, and has served on the boards of all three companies.[20]
Awards and honors
In addition to the Nobel Prize, Sharp has won several notable awards, including the 2004
Thomas R. Cech.[24]
Sharp is an elected member of several academic societies, including the
Foreign Member of the Royal Society (ForMemRS) in 2011.[29][30] In 2012, he was elected the president of the American Association for the Advancement of Science.[31] He is also a Member and Chair of the Scientific Advisory Board of Fidelity Biosciences Group; a member of the Board of Advisors of Polaris Venture Partners; chairman of the Scientific Advisory Board and member of the Board of Directors of Alnylam Pharmaceuticals
; advisor and investor at Longwood and Polaris Venture Funds; a member of the Boards of Directors at Syros Pharmaceuticals and VIR Biotechnology; and member and Chair of the Scientific Advisory Board at Dewpoint Biotechnology.
Pendleton County, Kentucky, Sharp's birthplace, named its current middle school after him.
Other activities
In October 2010 Sharp participated in the
MIT.[34]
He is an editorial advisor to
The Scripps Research Institute.[36] He has also served on the Faculty Advisory Board of the MIT-Harvard Research Journal and MIT Student Research Association.[15]
Selected publications
- Petersen C.P.; Bordeleau M.E.; Pelletier J.; Sharp P.A. (February 17, 2006). "Short RNAs Repress Translation after Initiation in Mammalian Cells". Mol Cell. 21 (4): 533–42. PMID 16483934.
- Cheng C.; Sharp P.A. (January 2006). "Regulation of CD44 Alternative Splicing by SRm160 and its Potential Role in Tumor Cell Invasion". Mol Cell Biol. 26 (1): 362–70. PMID 16354706.
- Tantin D.; Schild-Poulter C.; Wang V.; Hache R.J.; Sharp P.A. (December 1, 2005). "The Octamer Binding Transcription Factor Oct-1 is a Stress Sensor". Cancer Res. 65 (23): 10750–8. PMID 16322220.
- Grishok A.; Sharp P.A. (November 29, 2005). "Negative Regulation of Nuclear Divisions in Caenorhabditis Elegans by Retinoblastoma and RNA Interference-related Genes". Proc Natl Acad Sci U S A. 102 (48): 17360–5. PMID 16287966.
- Sharp P.A. (October 7, 2005). "1918 Flu and Responsible Science". Science. 310 (5745): 17. PMID 16210500.
- Miskevich F.; Doench J.G.; Townsend M.T.; Sharp P.A.; Constantine-Paton M. (April 15, 2006). "RNA Interference of Xenopus NMDAR NR1 in vitro and in vivo". J Neurosci Methods. 152 (1–2): 65–73. S2CID 25844342.
- Hong J.H.; Hwang E.S.; McManus M.T.; Amsterdam A.; Tian Y.; Kalmukova R.; Mueller E.; Benjamin T.; Spiegelman B.M.; Sharp P.A.; Hopkins N.; Yaffe M.B. (August 12, 2005). "TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation". Science. 309 (5737): 1074–8. S2CID 1958224.
- Houbaviy H.B.; Dennis L.; Jaenisch R.; Sharp P.A. (August 2005). "Characterization of a Highly Variable Eutherian microRNA Gene". RNA. 11 (8): 1245–57. PMID 15987809.
- Sharp P.A. (June 2005). "The Discovery of Split Genes and RNA Splicing". Trends Biochem. Sci. 30 (6): 279–81. PMID 15950867.
- Johnson D.M.; Yamaji S.; Tennant J.; Srai S.K.; Sharp P.A. (March 28, 2005). "Regulation of Divalent Metal Transporter Expression in Human Intestinal Epithelial Cells Following Exposure to Non-haem Iron". FEBS Lett. 579 (9): 1923–9. S2CID 26592792.
- Neilson J.R.; Sharp P.A. (April 2005). "Herpesviruses Throw a Curve Ball: New Insights into microRNA Biogenesis and Evolution". Nat Methods. 2 (4): 252–4. S2CID 930447.
- Grishok A.; Sinskey J.L.; Sharp P.A. (March 15, 2005). "Transcriptional Silencing of a Transgene by RNAi in the Soma of C. elegans". Genes Dev. 19 (6): 683–96. PMID 15741313.
- Sharp P.A.; Sharp, P (January 1, 2005). "Phillip Sharp Discusses RNAi, Nobel Prizes and Entrepreneurial Science". Drug Discov Today. 10 (1): 7–10. PMID 15676292.
- Lee K.B.; Sharp P.A. (December 7, 2004). "Transcription-dependent Polyubiquitination of RNA Polymerase II Requires Lysine 63 of Ubiquitin". Biochemistry. 43 (48): 15223–9. PMID 15568815.
- Mansfield J.H.; Harfe B.D.; Nissen R.; Obenauer J.; Srineel J.; Chaudhuri A.; Farzan-Kashani R.; Zuker M.; Pasquinelli A.E.; Ruvkun G.; Sharp P.A.; Tabin C.J.; McManus M.T. (October 2004). "MicroRNA-responsive 'Sensor' Transgenes Uncover Hox-like and Other Developmentally Regulated Patterns of Vertebrate MicroRNA Expression". Nat. Genet. 36 (10): 1079–83. PMID 15361871.
- Fairbrother W.G.; Holste D.; Burge C.B.; Sharp P.A. (September 2004). "Single Nucleotide Polymorphism-based Validation of Exonic Splicing Enhancers". PLOS Biol. 2 (9): E268. PMID 15340491.
- Novina C.D.; Sharp P.A. (July 8, 2004). "The RNAi Revolution". Nature. 430 (6996): 161–4. S2CID 4341565.
- Ventura A.; Meissner A.; Dillon C.P.; McManus M.; Sharp P.A.; Van Parijs L.; Jaenisch R.; Jacks T. (July 13, 2004). "Cre-lox-regulated Conditional RNA Interference from Transgenes". Proc Natl Acad Sci U S A. 101 (28): 10380–5. PMID 15240889.
See also
References
- ^ The Official Site of Louisa Gross Horwitz Prize
- ^ "The Nobel Prize in Physiology or Medicine 1993". Nobelprize.org. Nobel Media. Retrieved November 12, 2014.
- PMID 22586619.
- PMID 20590673.
- PMID 15676292.
- PMID 15182083.
- S2CID 53265935.
- ^ "Othmer Gold Medal". Science History Institute. Retrieved February 4, 2015.
- ^ Autobiography at the Nobel site
- ^ Sharp's Research at MIT Archived December 6, 2006, at the Wayback Machine
- Chemical Heritage Foundation.
- ^ "The Koch Institute: Phillip A. Sharp". ki.mit.edu. Retrieved February 11, 2020.
- ^ "Joseph W. Sharp -- Woodhead Funeral Home, Falmouth, KY". Archived from the original on October 28, 2014. Retrieved October 8, 2013.
- ^ "Phillip A. Sharp - Biographical". Nobelprize.org. Nobel Media AB. Retrieved November 12, 2014.
- ^ a b c d "Curriculum Vitae - Phillip A. Sharp, Ph.D." Sharp Lab. Retrieved November 12, 2014.
- ^ a b c "Short Bio - Phillip A. Sharp". Sharp Lab. Retrieved November 12, 2014.
- ^ "The Communiques of Freedom Club". The Anarchist Library. Retrieved 2021-06-24.
- ^ "Regina Barzilay, James Collins, and Phil Sharp join leadership of new effort on machine learning in health". MIT News | Massachusetts Institute of Technology. 3 October 2018. Retrieved November 13, 2020.
- ^ "People". J-Clinic. Retrieved November 13, 2020.
- ^ Biogen Idec, Inc. (2008). "Proxy statement for annual meeting of stockholders to be held on June 19, 2008 at 9:00 A.M., local time", 7.
- ^ "The President's National Medal of Science Recipient Details - Phillip A. Sharp". National Science Foundation. Retrieved November 12, 2014.
- ^ "Benjamin Franklin Medal for Distinguished Achievement in the Sciences Recipients". American Philosophical Society. Retrieved November 27, 2011.
- American Academy of Achievement.
- ^ "The Louisa Gross Horwitz Prize for Biology or Biochemistry". Columbia University Medical Center. Retrieved November 12, 2014.
- ^ "Alphabetical Index of Active Members" (PDF). American Academy of Arts and Sciences. November 5, 2013. Retrieved November 12, 2014.
- ^ "Fellows". American Association for the Advancement of Science. Archived from the original on July 27, 2014. Retrieved November 12, 2014.
- ^ "Phillip A. Sharp". National Academy of Sciences. Retrieved November 12, 2014.
- ^ "Directory: IOM Member - Phillip A. Sharp, Ph.D." Institute of Medicine of the National Academies. Archived from the original on November 12, 2014. Retrieved November 12, 2014.
- ^ "Professor Philip Sharp ForMemRS". London: Royal Society. Archived from the original on October 6, 2015.
- ^ "Royal Society". Royal Society. Retrieved March 20, 2010.
- ^ "Phillip A. Sharp, Molecular Biologist and Nobel Laureate, Chosen to Serve as AAAS President-Elect". American Association for the Advancement of Science. March 13, 2012. Retrieved November 12, 2014.
- ^ "Lunch with a Laureate". Archived from the original on April 21, 2010. Retrieved December 9, 2010.. usasciencefestival.org (2010)
- ^ Furthermore, Sharp participates in the Distinguished Lecture Series of the annual Research Science Institute (RSI), a summer research program for high school students held at MIT. Advisors Archived April 21, 2010, at the Wayback Machine. usasciencefestival.org
- ^ "MIT 150: The Top 50". boston.com. Retrieved November 12, 2014.
- ^ "About". xconomy.com. Retrieved November 12, 2014.
- ^ "Board of Scientific Governors". The Scripps Research Institute. Retrieved November 12, 2014.
External links
- Center for Oral History. "Phillip A. Sharp". Science History Institute.
- Thackray, Arnold; Brock, David C.; Ashiya, Mona (November 20, 2003). Phillip A. Sharp, Transcript of Interviews Conducted by Arnold Thackray, David C. Brock, and Mona Ashiya at Massachusetts Institute of Technology Cambridge, Massachusetts on 28 January, 29 May, and 20 November 2003 (PDF). Philadelphia, PA: Chemical Heritage Foundation.
- Phillip A. Sharp on Nobelprize.org
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