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Group of chemical compounds
12-O-tetradecanoylphorbol-13-acetate
, a phorbol ester
Phorbol esters are a class of chemical compounds found in a variety of plants, particularly in the families
.
Biological activity
Protein kinase C (PKC) is a phorbol ester receptor.[2][3] Phorbol esters can stimulate PKC in a similar way to diglycerides.[2][3]
Phorbol esters are known for their ability to
12-O-tetradecanoylphorbol-13-acetate (TPA) is used as a biomedical research tool in models of
carcinogenesis.
[4][5]Plants that contain phorbol esters are often poisonous.[5]
References
- .
- ^ , retrieved 2020-11-26
- ^ , retrieved 2020-11-26
- .
- ^ .
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| TRPA | |
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| TRPC | |
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| TRPM | |
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| TRPML | |
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| TRPP | |
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| TRPV | | Activators |
- 2-APB
- 5',6'-EET
- 9-HODE
- 9-oxoODE
- 12S-HETE
- 12S-HpETE
- 13-HODE
- 13-oxoODE
- 20-HETE
- )
- Allicin (garlic)
- AM404
- Anandamide
- Bisandrographolide (Andrographis paniculata)
- )
- Cannabidiol (cannabis)
- Cannabidivarin (cannabis)
- Capsaicin (chili pepper)
- Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)
- DHEA
- Diacyl glycerol
- Dihydrocapsaicin (chili pepper)
- Estradiol
- Eugenol (basil, clove)
- Evodiamine (Euodia ruticarpa)
- Gingerols (ginger)
- GSK1016790A
- Heat
Hepoxilin A3 Hepoxilin B3 - Homocapsaicin (chili pepper)
- Homodihydrocapsaicin (chili pepper)
- Incensole (incense)
- Lysophosphatidic acid
- Low pH (acidic conditions)
- Menthol (mint)
- N-Arachidonoyl dopamine
- N-Oleoyldopamine
- N-Oleoylethanolamide
- Nonivamide (PAVA) (PAVA spray)
- Nordihydrocapsaicin (chili pepper)
- Paclitaxel (Pacific yew)
- Paracetamol (acetaminophen)
- Phenylacetylrinvanil
- Phorbol esters (e.g., 4α-PDD)
- Piperine (black pepper, long pepper)
- Polygodial (Dorrigo pepper)
- Probenecid
- Protons
- RhTx
- Rutamarin (Ruta graveolens)
- Resiniferatoxin (RTX) (Euphorbia resinifera/pooissonii)
- Shogaols (ginger, Sichuan and melegueta peppers)
- Tetrahydrocannabivarin (cannabis)
- Thymol (thyme, oregano)
- Tinyatoxin (Euphorbia resinifera/pooissonii)
- Tramadol
- Vanillin (vanilla)
- Zucapsaicin
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| Blockers | |
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