6-Phosphogluconate dehydrogenase
(Redirected from
Phosphogluconate dehydrogenase
)| 6PGD | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Phosphogluconate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
ExPASy NiceZyme view | | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| phosphogluconate dehydrogenase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PGD | ||||||
Chr. 1 p36.3-36.13 | |||||||
| |||||||
6-Phosphogluconate dehydrogenase (6PGD) is an
6-phosphogluconate
:
- 6-phospho-D-gluconate + NAD(P)+ D-Ribulose 5-phosphate + CO2 + NAD(P)H + H+
It is an oxidative carboxylase that
binding in an adjacent pocket.[3]
Biotechnological significance
Recently, 6PGD was demonstrated to catalyze also the reverse reaction (i.e. reductive
carbon fixation
routes.
Clinical significance
Mutations within the gene coding this enzyme result in
autosomal
hereditary disease affecting the red blood cells.
As a possible drug target
6PGD is involved in cancer cell metabolism so 6PGD inhibitors have been sought.[6]
See also
- Parietin, a 6PGD inhibitor
References
Further reading
- Frampton EW, Wood WA (October 1961). "Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate". The Journal of Biological Chemistry. 236: 2571–7. PMID 13894458.
