Phytochemistry
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Phytochemistry is the study of phytochemicals, which are chemicals derived from plants. Phytochemists strive to describe the structures of the large number of secondary metabolites found in plants, the functions of these compounds in human and plant biology, and the biosynthesis of these compounds. Plants synthesize phytochemicals for many reasons, including to protect themselves against insect attacks and plant diseases. The compounds found in plants are of many kinds, but most can be grouped into four major biosynthetic classes: alkaloids, phenylpropanoids, polyketides, and terpenoids.
Phytochemistry can be considered a subfield of botany or chemistry. Activities can be led in botanical gardens or in the wild with the aid of ethnobotany. Phytochemical studies directed toward human (i.e. drug discovery) use may fall under the discipline of pharmacognosy, whereas phytochemical studies focused on the ecological functions and evolution of phytochemicals likely fall under the discipline of chemical ecology. Phytochemistry also has relevance to the field of plant physiology.
Techniques
Techniques commonly used in the field of phytochemistry are
Phytochemicals
Many plants produce chemical compounds
Many phytochemicals, including curcumin, epigallocatechin gallate, genistein, and resveratrol are pan-assay interference compounds and are not useful in drug discovery.[4][5]
Alkaloids
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The alkaloid nicotine from tobacco binds directly to the body's Nicotinic acetylcholine receptors, accounting for its pharmacological effects.[8]
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Deadly nightshade, Atropa belladonna, yields tropane alkaloids including atropine, scopolamine and hyoscyamine.[6]
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N,N-Dimethyltryptamine (DMT) a powerful psychedelic compound which is present in several plant species found across the globe, commonly found in Mimosa and Acacia species but has also been discovered in grasses such as Philaris Aquatica.
Glycosides
The
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Thefoxglove, Digitalis purpurea, contains digoxin, a cardiac glycoside. The plant was used to treat heart conditions long before the glycoside was identified.[11][12]
Polyphenols
Polyphenols of several classes are widespread in plants, including anthocyanins, phytoestrogens, and tannins.[13] Polyphenols are secondary metabolites produced by almost every part of plants, including fruits, flowers, leaves and bark.[13]
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Angelica, containing phytoestrogens
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Polyphenols include phytoestrogens (top and middle)
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Anthocyanins are a class of polyphenol that contributes to the color of many plants.
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Tannic acids are one example of many complex polyphenolic structures produced by plants.
Terpenes
Genetics
Contrary to bacteria and fungi, most plant
References
- ^ "Angiosperms: Division Magnoliophyta: General Features". Encyclopædia Britannica (volume 13, 15th edition). 1993. p. 609.
- ISBN 978-1-58716-083-7.
- ISBN 978-0-387-85497-7.
- PMID 25254460.
- PMID 25163000.
- ^ a b "Atropa Belladonna" (PDF). The European Agency for the Evaluation of Medicinal Products. 1998. Archived from the original (PDF) on 17 April 2018. Retrieved 26 February 2017.
- S2CID 25434984.
- ^ "Nicotinic acetylcholine receptors: Introduction". IUPHAR Database. International Union of Basic and Clinical Pharmacology. Archived from the original on 29 June 2017. Retrieved 26 February 2017.
- ^ PMID 3671329.
- ISBN 9781489917782.
- ^ a b c "Active Plant Ingredients Used for Medicinal Purposes". United States Department of Agriculture. Retrieved 18 February 2017.
- ^ "Digitalis purpurea. Cardiac Glycoside". Texas A&M University. Archived from the original on 2 July 2018. Retrieved 26 February 2017.
The man credited with the introduction of digitalis into the practice of medicine was William Withering.
- ^ a b "Flavonoids". Micronutrient Information Center, Linus Pauling Institute, Oregon State University. 1 February 2016. Retrieved 11 October 2023.
- JSTOR 27836252.
- JSTOR 2588737.
- ^ a b c "Thymol (CID=6989)". NIH. Retrieved 26 February 2017.
THYMOL is a phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent. It was formerly used as a vermifuge.
- ISSN 2160-3855.
- S2CID 219947907.