Pildralazine

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Pildralazine
Clinical data
Other namesISF-2123
Routes of
administration		Oral
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-[(6-Hydrazinylpyridazin-3-yl)(methyl)amino]propan-2-ol
JSmol)
  • n1nc(NN)ccc1N(C)CC(O)C
  • InChI=1S/C8H15N5O/c1-6(14)5-13(2)8-4-3-7(10-9)11-12-8/h3-4,6,14H,5,9H2,1-2H3,(H,10,11)
  • Key:KYIAWOXNPBANEW-UHFFFAOYSA-N

Pildralazine (Atensil), also known as propyldazine or propildazine, is an

vasodilator.[1]

Synthesis

Thieme Synthesis:[2] Patent:[3]

The reaction between 3,6-Dichloropyridazine [141-30-0] (1) and 1-(Methylamino)-2-propanol [16667-45-1] (2) gives CID:12237595 (3). Reaction with hydrazine completes the synthesis of Pidralazine (4).

References

  1. ISBN 978-0-412-46630-4
    . Retrieved 25 November 2011.
  2. PMID 1151996
    .
  3. ^ DE2154245 idem G Pifferi, U.S. patent 3,769,278 (1973 to Isf Spa).
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