Piroxicam
Clinical data | |
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Pronunciation | /paɪˈrɒksɪˌkæm/ |
Trade names | Feldene, others[1] |
Other names | Piroksikam, piroxikam |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684045 |
Pregnancy category |
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Routes of administration | By mouth |
ATC code | |
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Pharmacokinetic data | |
Protein binding | 99%[4] |
Metabolism | Liver-mediated hydroxylation and glucuronidation[4] |
Elimination half-life | 50 hours[4] |
Excretion | Urine, faeces |
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Piroxicam is a
It was patented in 1968 by Pfizer and approved for medical use in 1979.[7] It became generic in 1992,[8] and is marketed worldwide under many brandnames.[1]
Medical uses
It is used in the treatment of certain inflammatory conditions like
Adverse effects
As with other NSAIDs the principal side effects include: digestive complaints like
In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[10][11] They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[10][11]
Mechanism of action
Piroxicam is an NSAID and, as such, is a non-selective
Chemical properties
Piroxicam exists as alkenol tautomer in organic solvents and as zwitterionic form in water.[12]
History
The project that produced piroxicam began in 1962 at Pfizer; the first clinical trial results were reported in 1977, and the product launched in 1980 under the brand name "Feldene".[8][13] Major patents expired in 1992[8] and the drug is marketed worldwide under many brandnames.[1]
See also
References
- ^ a b c "International listings for piroxicam". Drugs.com. Retrieved 3 July 2015.
- FDA. Retrieved 22 Oct 2023.
- ^ "Active substance: piroxicam" (PDF). List of nationally authorised medicinal products. European Medicines Agency. 10 December 2020.
- ^ a b c d e f g Brayfield A, ed. (14 January 2014). "Piroxicam". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Archived from the original on 28 August 2021. Retrieved 24 June 2014.
- ^ "TGA Approved Terminology for Medicines, Section 1 – Chemical Substances" (PDF). Therapeutic Goods Administration, Department of Health and Ageing. Australian Government. July 1999. p. 97.
- ^ ISBN 978-0-85711-084-8.
- ISBN 9783527607495.
- ^ Box 1: Discovery of piroxicam (1962–1980)
- ^ "Committee for medicinal products for human use (CHMP) opinion following an Article 31(2) referral for Piroxicam containing medicinal products" (PDF). European Medicines Agency. London, UK. 20 September 2007. Retrieved 24 June 2014.
- ^ a b "FDA Warns that Using a Type of Pain and Fever Medication in Second Half of Pregnancy Could Lead to Complications". U.S. Food and Drug Administration (FDA) (Press release). 15 October 2020. Retrieved 15 October 2020. This article incorporates text from this source, which is in the public domain.
- ^ a b "NSAIDs may cause rare kidney problems in unborn babies". U.S. Food and Drug Administration. 21 July 2017. Retrieved 15 October 2020. This article incorporates text from this source, which is in the public domain.
- .
- PMID 342691.
Further reading
- Dean L (2019). "Piroxicam Therapy and CYP2C9 Genotype". In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.). Medical Genetics Summaries. PMID 30742401. Bookshelf ID: NBK537367.