Pituitary adenylate cyclase-activating peptide
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| Location (UCSC) | Chr 18: 0.9 – 0.91 Mb | Chr 17: 93.51 – 93.51 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 gene.[5][6] pituitary adenylate cyclase-activating polypeptide is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to vasoactive intestinal peptide receptor and to the pituitary adenylate cyclase-activating polypeptide receptor.
Function
This gene encodes adenylate cyclase-activating polypeptide 1. Mediated by adenylate cyclase-activating polypeptide 1 receptors, this polypeptide stimulates
3' UTR. This gene encodes three different mature peptides, including two isotypes: a shorter form and a longer form.[6]
A version of this gene has been associated with
bed nucleus of the stria terminalis.[8]
Headache Disorders
Both isoforms of pituitary adenylate cyclase-activating polypeptide (pituitary adenylate cyclase-activating polypeptide-38 and pituitary adenylate cyclase-activating polypeptide-27) have been implicated in
Amgen's AMG-301, which targets the PAC1 receptor, failed to show greater efficacy than placebo in phase II trials.[13]
Interactions
Pituitary adenylate cyclase-activating peptide has been shown to
interact with secretin receptor.[14]
See also
- Adenylate cyclase
- Pituitary gland
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000141433 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024256 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1730060.
- ^ a b "Entrez Gene: ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)".
- PMID 21350482.
- PMID 38053471.
- ^ PMID 19052139.
- ^ S2CID 196349669.
- PMID 31291018.
- ^ "Alder BioPharmaceuticals® Announces First-in-Human Dosing in Phase 1 ALD1910 Study for Preventive Treatment of Migraine". Globenewswire News Room. GlobeNewswire. 10 October 2019. Retrieved 10 October 2019.
- PMID 33231489.
- PMID 1335692.
Further reading
- Conconi MT, Spinazzi R, Nussdorfer GG (2006). Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland. International Review of Cytology. Vol. 249. pp. 1–51. PMID 16697281.
- Cross SH, Charlton JA, Nan X, Bird AP (March 1994). "Purification of CpG islands using a methylated DNA binding column". Nature Genetics. 6 (3): 236–44. S2CID 12847618.
- Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL (December 1999). "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology. 11 (12): 941–9. S2CID 35761617.
- Fahrenkrug J (2002). "Gut/brain peptides in the genital tract: VIP and PACAP". Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum. 61 (234): 35–9. S2CID 7249967.
- Fahrenkrug J (2006). "PACAP--a multifacetted neuropeptide". Chronobiology International. 23 (1–2): 53–61. S2CID 29584195.
- Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT (December 1992). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". The American Journal of Physiology. 263 (6 Pt 1): G901-7. PMID 1335692.
- Geng L, Ju G (January 1997). "[The discovery of pituitary adenylate cyclase activating polypeptide (PACAP) and its research progress]". Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. 28 (1): 29–34. PMID 10921074.
- Gourlet P, Vandermeers A, Robberecht P, Deschodt-Lanckman M (August 1997). "Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP-27, but not PACAP-38) degradation by the neutral endopeptidase EC 3.4.24.11". Biochemical Pharmacology. 54 (4): 509–15. PMID 9313778.
- Inagaki N, Yoshida H, Mizuta M, Mizuno N, Fujii Y, Gonoi T, et al. (March 1994). "Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells". Proceedings of the National Academy of Sciences of the United States of America. 91 (7): 2679–83. PMID 8146174.
- Inooka H, Endo S, Kitada C, Mizuta E, Fujino M (November 1992). "Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution". International Journal of Peptide and Protein Research. 40 (5): 456–64. PMID 1483839.
- Kimura C, Ohkubo S, Ogi K, Hosoya M, Itoh Y, Onda H, et al. (January 1990). "A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs". Biochemical and Biophysical Research Communications. 166 (1): 81–9. PMID 2302217.
- Nakata M, Yada T (2007). "PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential". Current Pharmaceutical Design. 13 (11): 1105–12. PMID 17430174.
- Ohkubo S, Kimura C, Ogi K, Okazaki K, Hosoya M, Onda H, et al. (1992). "Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide". DNA and Cell Biology. 11 (1): 21–30. PMID 1739432.
- Ohtaki T, Masuda Y, Ishibashi Y, Kitada C, Arimura A, Fujino M (December 1993). "Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide". The Journal of Biological Chemistry. 268 (35): 26650–7. PMID 8253796.
- Pérez-Jurado LA, Francke U (June 1993). "Dinucleotide repeat polymorphism at the human pituitary adenylate cyclase activating polypeptide (PACAP) gene". Human Molecular Genetics. 2 (6): 827. PMID 8353512.
- Vaudry D, Falluel-Morel A, Bourgault S, Basille M, Burel D, Wurtz O, et al. (September 2009). "Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery". Pharmacological Reviews. 61 (3): 283–357. S2CID 5739004.
- Waschek JA (2002). "Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration". Developmental Neuroscience. 24 (1): 14–23. S2CID 22281905.
- Weber B, Riess O, Daneshvar H, Graham R, Hayden MR (June 1993). "(CA)n-dinucleotide repeat at the PDEB locus in 4p16.3". Human Molecular Genetics. 2 (6): 827. PMID 8394765.
- Wray V, Kakoschke C, Nokihara K, Naruse S (June 1993). "Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy". Biochemistry. 32 (22): 5832–41. PMID 8504103.
- Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, et al. (November 1999). "PACAP type I receptor activation regulates ECL cells and gastric acid secretion". The Journal of Clinical Investigation. 104 (10): 1383–91. PMID 10562300.
External links
- Pituitary+adenylate+cyclase-activating+polypeptide at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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