Plant expressed vaccine

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Plant expressed vaccine or project GreenVax

swine flu pandemic that highlighted the national need for rapid and agile vaccine manufacturing capabilities.[3] The Texas A&M University and a Texas company (GreenVax LLC, later renamed to Caliber Biotherapeutics LLC and ultimately acquired by iBio, Inc.) have been awarded a $40 million U.S. Department of Defense grant to develop a plant expressed vaccine made from tobacco.[4] While egg-based vaccines typically take more than six months to develop after a virus is isolated, the new process will take only four to six weeks.[4] The vice chancellor for research at A&M System declared that if the project works it will be one of the largest and most capable vaccine facilities in the world.[4] However the major problem is the public acceptance of this technology, many of the companies are looking for the FDA approval [5]

The plant-based vaccine production method works by isolating a specific antigen protein, one that triggers a human immune response from the targeted virus. A gene from the protein is transferred to bacteria, which are then used to “infect” plant cells. The plants then start producing the exact protein that will be used for vaccinations.

Norwalk virus.[7]

References

  1. ^ "Archived copy" (PDF). Archived from the original (PDF) on 2010-05-24. Retrieved 2010-08-06.{{cite web}}: CS1 maint: archived copy as title (link)
  2. ^ "Food as a weapon". Archived from the original on 2016-03-03. Retrieved 2010-08-06.
  3. ^ "Scalable Manufacturing of Plant-Expressed Vaccines". DARPA. Archived from the original on 5 March 2016. Retrieved 6 August 2010.
  4. ^ a b c "A&M gets big grant to make tobacco-based vaccine". Houston Chronicle. 24 February 2010. Retrieved 6 August 2010.
  5. ^ McIntosh, Dwayne D. Kirk and Kim (2006-01-24). "Social Acceptance of Plant-Made Vaccines: Indications from a Public Survey". www.agbioforum.org. Retrieved 2018-04-03.
  6. ^ Drummond, Katie (24 February 2010). "Darpa-funded Researchers: Tobacco vs. Viral Terror". Wired.
  7. ^ Drummond, Katie (24 February 2010). "Darpa-funded Researchers: Tobacco vs. Viral Terror". Wired.
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