Blood protein
(Redirected from
Plasma proteins
)Blood-proteins, also termed plasma proteins, are
haemoglobin is not a blood protein, as it is carried within red blood cells, rather than in the blood serum
.
Families of blood proteins
| Blood protein | Normal level | % | Function |
|---|---|---|---|
| Albumins | 3.5-5.0 g/dl | 55% | create and maintain osmotic pressure; transport insoluble molecules |
| Globulins | 2.0-2.5 g/dl | 38% | participate in immune system |
| Fibrinogen | 0.2-0.45 g/dl | 7% | Blood coagulation |
| Regulatory proteins | <1% | Regulation of gene expression | |
| Clotting factors | <1% | Conversion of fibrinogen into fibrin |
Examples of specific blood proteins:
- Prealbumin (transthyretin)
- digestive system)
- Alpha-1-acid glycoprotein
- Alpha-1-fetoprotein
- alpha2-macroglobulin
- Gamma globulins
- Beta-2 microglobulin
- Haptoglobin
- Human Serum Albumin
- Ceruloplasmin
- Complement component 3
- Complement component 4
- C-reactive protein (CRP)
- HDL)
- Transferrin
- Prothrombin
- MBL or MBP
Clinical significance
Separating
serum proteins by electrophoresis is a valuable diagnostic tool, as well as a way to monitor clinical progress. Current research regarding blood plasma proteins is centered on performing proteomics analyses of serum/plasma in the search for biomarkers. These efforts started with two-dimensional gel electrophoresis[2] efforts in the 1970s, and in more recent times this research has been performed using LC-tandem MS[3][4] based proteomics. The normal laboratory value of serum total protein
is around 7 g/dL.
Scientists are able to identify blood proteins using Photo-affinity labeling, a means of using photo-reactive ligands as a labeling agent to identify targeted proteins.[5]
References
- ^ ISBN 978-0-12-415759-0, retrieved 2020-11-16
- PMID 271964.
- PMID 12543931.
- PMID 26732734.
- PMID 24217326.
- Clinical Chemistry : a laboratory perspective / [edited by] Wendy Arneson, Jean Brickell.
| Authority control databases: National |
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