Plasmodium chabaudi
| Plasmodium chabaudi | |
|---|---|
Scientific classification 
| |
| Domain: | Eukaryota |
| Clade: | Diaphoretickes |
| Clade: | SAR |
| Clade: | Alveolata |
| Phylum: | Apicomplexa |
| Class: | Aconoidasida |
| Order: | Haemospororida |
| Family: | Plasmodiidae |
| Genus: | Plasmodium |
| Subgenus: | Vinckeia |
| Species: | P. chabaudi
|
| Binomial name | |
| Plasmodium chabaudi Landau, 1965
| |
| Subspecies | |
Plasmodium chabaudi is a parasite of the genus Plasmodium subgenus Vinckeia. As in all Plasmodium species, P. chabaudi has both vertebrate and insect hosts. The vertebrate hosts for this parasite are rodents.[1]
Taxonomy
This species was described in 1965 by Irène Landau.[2] It is named after the French parasitologist Alain Chabaud.
Subspecies
Two subspecies have been defined: P. chabaudi chabaudi and P. chabaudi adami.[3]
Genome
The nuclear genome is 18.8
Distribution
P. chabaudi is found in Africa. It was first isolated from the blood of a shining thicket rat (
Hosts
While it is difficult to study P. chabaudi in its natural host given the difficulty of taming the thicket rat, it has been studied extensively in laboratory mice, largely using the clone P. chabaudi chabaudi (AS). The pathology resembles that of human malaria in that animals are susceptible to parasite growth and pathology such as anemia, hypoglycemia, changes in body temperature, weight loss, and occasional death. The other cloned strains vary in growth rates and virulence.[5] One unique feature of this species is its prolonged course of infection. While it seems to persist for years in the thicket rat, P. chabaudi (AS) lasts up to three months in BALB/c or C57Bl/6 mice [6] P. falciparum has been observed to persist for up to a year,[7] and even in conditions of drought when there are no new infections.[8] Other species that are used to model human infection do not have this property. The other unique properties of this parasite are that it is synchronous, as first described for malaria by Galen, and that it prefers to infect normocytes, similar to P. falciparum, the most virulent human parasite, while several of the other rodent parasites have a preference for immature red blood cells, or reticulocytes, which they share with P. vivax.
In
Host resistance
Peak
Lifecycle
There is usually a high female-to-male ratio in mature infections but this inhibits transmission at low densities due to lack of any male partner at the beginning of a new infection.[11][12][13] Therefore Reece et al., 2008 find P. chabaudi will bias toward a more even ratio at lower densities and when several clonal lineages are competing with each other in the same host.[11][12][13] This is believed to generalize beyond this species, to all Plasmodium.[11][12][13]
Therapeutic uses
P. chabaudi can reduce
External links
References
- ISBN 978-1-55581-111-2.
- ^ Landau I (1965). "Description de Plasmodium chabaudi n. sp., parasite de rongeurs africains". C. R. Acad. Sci. 260: 3758–3761.
- PMID 800328.
- PMID 4163669.
- PMID 22100995.
- S2CID 24676716.
- PMID 12201582.
- S2CID 25489689.
- ^ S2CID 81985222.
- PMID 15306410.
- ^ S2CID 27743505.
- ^ S2CID 30059984.
- ^ S2CID 20524090.
- S2CID 3234263.
