Plasmodium yoelii
| Plasmodium yoelii | |
|---|---|
Scientific classification 
| |
| Domain: | Eukaryota |
| Clade: | Diaphoretickes |
| Clade: | SAR |
| Clade: | Alveolata |
| Phylum: | Apicomplexa |
| Class: | Aconoidasida |
| Order: | Haemospororida |
| Family: | Plasmodiidae |
| Genus: | Plasmodium |
| Species: | P. yoelii
|
| Binomial name | |
| Plasmodium yoelii Landau, Michel and Adam, 1968
| |
| Subspecies | |
Plasmodium yoelii is a parasite of the genus
Taxonomy
This species was described in 1968 by Landau, Michel and Adam. Three subspecies are recognised:
Strains
- P. yoelii 17XNL[1]
Distribution
This species occurs in Africa.
Vectors
The natural vectors of this species are not currently known. One possible is the female Anopheles mosquito which serves as a vector for Plasmodium vivax.
Hosts
This species infects
Pathogenesis
P. yoelii impairs immune responses including impairing responses to other pathogens. Fewer granulocytes move out from the bone marrow and in a separate action induces the rodent's own
Notes
It is used in the laboratory to infect
One of the special things about this particular model is that it has two strains with vastly different pathogenicity. These are generally referred to as the "lethal" and "non-lethal" strains of the species. Comparison of these two strains can be used to deduce which factors may contribute to more serious malaria infections in humans.
References
- ^ S2CID 204882296.
Further reading
- Charoenvit, Yupin; Leef, Mary; Yuan, Leo; Sedegah, Martha; Beaudoin, Richard (March 1987). "Characterization of Plasmodium yoelii Monoclonal Antibodies Directed Against Stage-specific Sporozoite Antigens". Infection and Immunity. 55 (1987): 604–608. PMID 2434426.
- Keitany, Gladys J.; Sack, Brandon; Smithers, Hannah; Chen, Lin; Jang, Ihn K.; Sebastian, Leslie (December 2012). "Immunization of Mice with Live-Attenuated Late Liver Stage-Arresting Plasmodium yoelii Parasites Generates Protective Antibody Responses to Preerythrocytic Stages of Malaria". Infection and Immunity. 82 (12): 5143–5153. PMID 25267837.
- White, Chelsi E.; Villarino, Nicolas F.; Sloan, Sarah S.; Ganusov, Vitaly V.; Schmidt, Nathan W. (10 December 2014). "Plasmodium Suppresses Expansion of T Cell Responses to Heterologous Infections". The Journal of Immunology. 194 (2): 697–708. PMID 25505280.
- Valeelat O., Okeola; Oluwatosin A., Adaramoye; Chiaka M., Nneji (January 2011). "Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis". Parasitology Research. 108 (6): 1507–1512. S2CID 7428497.
- Harupa, Anke; Sack, Brandon; Lashmanan, Viswanathan (2014). "SSP3 Is a Novel Plasmodium yoelii Sporozoite Surface Protein with a Role in Gliding Motility". Infection and Immunity. 82 (11): 4643–4653. PMID 25156733.
- Kaushansky, Alexis; Austin, Laura S.; Mikolajczak, Sebastian A.; Fang, Y. Lo; Miller, Jessica A.; Douglass, Alyse N.; Arang, Nadia; Vaughan, Ashley M.; Gardner, Malcolm J.; Kappe, Stefan H. I. (January 2015). "Susceptibility to Plasmodium yoelii Preerythrocytic Infection in BALB/c Substrains Is Determined at the Point of Hepatocyte Invasion". Infection and Immunity. 83 (1): 39–47. PMID 25312960.
External links
- Information about the genome and genes of P. yoelii
| Authority control databases: National |
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