Platelet membrane glycoprotein
Platelet membrane glycoproteins are surface
Receptors involved in platelet adhesion to collagen
Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV as well, function as collagen receptors, engaged in platelet adhesion to collagen. The leading role in the elimination of high-stress injury is taken by the glycoprotein Ib-IX-V complex.
Interactions of the platelet surface glycoproteins
The binding of von Willebrand factor (vWF) results in conformational changes within the GPIb-V-IX complex. In consequence, this complex activates GPIIb / IIIa membrane glycoproteins, allowing them to bind fibrinogen. Fibrinogen molecules then interconnect the platelets, serving as the basis for platelet aggregation. In the absence of fibrinogen, the platelets are joined by vWF due to its ability to bind the activated GPIIb / IIIa complex.
Membrane glycoproteins
Glycoprotein Ib-IX-V complex (GPIb-IX-V)
This transmembrane glycoprotein complex is composed of four subunits:
Glycoprotein VI (GPVI)
Glycoprotein VI is one of the
Glycoprotein Ia / IIa complex (β1)
This is a receptor for
Glycoprotein IIb / IIIa complex (β3)
This complex interacts with
Fibrinogen sites recognized by glycoprotein IIb / IIIa complex:
- dodecapeptide located in the C-terminal of the fibrinogen γ chain (the most important)
- RGD sequence of the α chain → the Aspartateamino acid sequence
This complex also binds vWF,
GPV / IIIa (β1)
This is a
References
- PMID 10961879.
- ^ ESTAVILLO, RITCHIE, DIACOVO a CRUZ. Functional Analysis of a Recombinant Glycoprotein Ia/IIa (Integrin α2β1) I Domain That Inhibits Platelet Adhesion to Collagen and Endothelial Matrix under Flow Conditions. The Journal of Biological Chemistry,. s. -. DOI: 10.1074/jbc.274.50.35921. Available online: http://www.jbc.org/content/274/50/35921.long
- ISSN 0021-9258. Available online: http://www.jbc.org/content/260/20/11107.short
External links
- Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4): 346–60. PMID 7535429.
- GARNER, CAMPBELL a METCALFE. Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia. Blood. 2002. ISSN 1528-0020. DOI: 10.1182/blood.V100.1.344.Available online: http://bloodjournal.hematologylibrary.org/content/100/1/344.full.pdf
- Dumin, J A; Dickeson S K, Stricker T P, Bhattacharyya-Pakrasi M, Roby J D, Santoro S A, Parks W C (Aug. 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. (United States) 276 (31): 29368–74. DOI:10.1074/jbc.M104179200. PMID 11359786.
- http://www.reference.md/files/D019/mD019038.html
- Online Medical Dictionary, Platelet membrane glycoproteins
- Platelet+membrane+glycoproteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- http://www.ojrd.com/content/1/1/46/figure/F1?highres=y
- http://circ.ahajournals.org/content/99/1/e1/F4.large.jpg