Plazomicin

Source: Wikipedia, the free encyclopedia.

Plazomicin
Clinical data
Pronunciationpla" zoe mye' sin
Trade namesZemdri
Other namesACHN-490,
6'-(Hydroxylethyl)-1-(HABA)-sisomicin
AHFS/Drugs.comMonograph
MedlinePlusa618037
License data
Routes of
administration		Intravenous
Drug classAminoglycoside
ATC code
Legal status
Legal status
Identifiers
  • (2S)-4-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[[(2S,3R)-3-amino-6-[(2-hydroxyethylamino)methyl]-3,4-dihydro-2H-pyran-2-yl]oxy]-2-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
JSmol)
  • CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3OC(=CC[C@H]3N)CNCCO)[C@@H](N)C[C@H]2NC(=O)[C@@H](O)CCN)OC[C@]1(C)O
  • InChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1
  • Key:IYDYFVUFSPQPPV-PEXOCOHZSA-N

Plazomicin, sold under the brand name Zemdri, is an

injection into a vein.[2]

Common side effects include

Clostridium difficile-associated diarrhea, anaphylaxis, and muscle weakness.[2] Use during pregnancy may harm the baby.[2] Plazomicin works by decreasing the ability of bacteria to make protein.[2]

Plazomicin was approved for medical use in the United States in 2018.[3][4] It is on the World Health Organization's List of Essential Medicines.[5]

Medical uses

Plazomicin is approved by the U.S. Food and Drug Administration (FDA) for adults with complicated urinary tract infections, including pyelonephritis, caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Enterobacter cloacae, in patients who have limited or no alternative treatment options. Zemdri is an intravenous infusion, administered once daily.[6][7][8][9] The FDA declined approval for treating bloodstream infections due to lack of demonstrated effectiveness.[3] The lack of demonstrated effectiveness was not so much about the antibiotic itself being ineffective so much as the low enrollment rate for the study. Studies using mouse models however, showed a high survival rate.[10]

Plazomicin has been reported to demonstrate in vitro synergistic activity when combined with daptomycin or ceftobiprole versus methicillin-resistant Staphylococcus aureus, vancomycin-resistant S. aureus and against Pseudomonas aeruginosa when combined with cefepime, doripenem, imipenem or piperacillin/tazobactam.[11] It also demonstrates potent in vitro activity versus carbapenem-resistant Acinetobacter baumannii.[12] Plazomicin was found to be noninferior to meropenem.[13][14]

History

The drug was developed by the biotech company Achaogen. In 2012, the U.S. Food and Drug Administration granted fast track designation for the development and regulatory review of plazomicin.[15] The FDA approved plazomicin for adults with complicated UTIs and limited or no alternative treatment options in 2018.[6] Achaogen was unable to find a robust market for the drug, and declared bankruptcy a few months later.[16] A generic version is manufactured by Cipla USA.[17]

Synthesis

It is derived from sisomicin by appending a hydroxy-aminobutyric acid substituent at position 1 and a hydroxyethyl substituent at position 6'.[18][11] The latter makes it impervious to acetylation (deactivation) by Aminoglycoside Acetyltransferase 6'-N- Type Ib (AAC(6')-Ib), the most prevalent AAC enzyme.[19]

Names

Plazomicin is the international nonproprietary name (INN).[20]

References

  1. FDA
    . Retrieved 22 October 2023.
  2. ^ a b c d e f g "Plazomicin Sulfate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 10 October 2019.
  3. ^ a b "FDA Approved Drug Products: Zemdri". U.S. Food and Drug Administration. Retrieved 28 June 2018.
  4. ^ "Drug Approval Package: Zemdri (plazomicin)". U.S. Food and Drug Administration. 5 July 2018. Retrieved 25 December 2019.
  5. hdl:10665/325771
    . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ^ a b "Zemdri (plazomicin)- plazomicin injection". DailyMed. 30 July 2020. Retrieved 11 October 2020.
  7. ^ "plazomicin (Rx)". Medscape. Retrieved 14 September 2019.
  8. ^ Brown T (3 May 2018). "FDA Panel Recommends Plazomicin for cUTI but Not BSI". Medscape. Retrieved 14 September 2019.
  9. ^ "BioCentury - FDA approves plazomicin for cUTI, but not blood infections". www.biocentury.com. Retrieved 28 June 2018.
  10. ^ https://www.fda.gov/media/113289/download
  11. ^
    S2CID 31496981
    .
  12. PMID 26169398
    .
  13. ^ Clinical trial number NCT02486627 for "A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) (EPIC)" at ClinicalTrials.gov
  14. PMID 30786187
    .
  15. ^ "Achaogen Announces Plazomicin Granted QIDP Designation by FDA" (Press release). Achaogen, Inc. 8 January 2015. Retrieved 27 April 2016 – via GlobeNewswire.
  16. ^ Jacobs A (25 December 2019). "Crisis Looms in Antibiotics as Drug Makers Go Bankrupt". The New York Times.
  17. ^ "Generic Zemdri Availability". Drugs.com. Retrieved 26 December 2019.
  18. PMID 20805391
    .
  19. PMID 29634241
    .
  20. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended INN: List 68". WHO Drug Information. 26 (3). World Health Organization: 314. September 2012. Archived from the original on 2 October 2014. Retrieved 27 April 2016.

Further reading

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