Polidocanol
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| Routes of administration | topical, subcutaneous injection |
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JSmol) | |
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Polidocanol is a
eczema and dry skin.[2] It has also been used to treat varicose veins,[3] hemangiomas, and vascular malformations.[4] It is formed by the ethoxylation of dodecanol
.
Sclerotherapy
Polidocanol is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera, Aethoxysklerol[5] and Varithena.[6] Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.
The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of
Polidocanol in the form of Varithena injected in the greater saphenous vein can cause the eruption of varicose and spider veins throughout the lower leg. This procedure should be done with caution and with the knowledge that the appearance of the leg may be forever compromised.
References
- ^ "Health Canada New Drug Authorizations: 2015 Highlights". Health Canada. 4 May 2016. Retrieved 7 April 2024.
- ^ "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.
- PMID 28166694.
- PMID 29082587.
- ^ Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
- ^ "Varithena (polidocanol injectable foam) For Intravenous Use. Full Prescribing Information" (PDF). Biocompatibles, Inc. Archived from the original (PDF) on 4 August 2016. Retrieved 1 October 2015.
- ^ Facts and Companies: Varicose Vein Treatment Approved
- ^ "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.