Polyhexanide
Names | |
---|---|
Other names
Polyhexamethylene biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide
| |
Identifiers | |
Abbreviations | PHMB |
ChEBI | |
ChemSpider |
|
UNII | |
CompTox Dashboard (EPA)
|
|
Properties | |
(C8H17N5)n | |
Pharmacology | |
D08AC05 (WHO) S01AX24 (WHO) | |
Hazards | |
GHS labelling:[1] | |
Danger | |
H302, H317, H318, H330, H351, H372, H410 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Polyhexanide (polyhexamethylene biguanide, PHMB) is a
Products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection.[5] PHMB eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.[6]
It is sold as a swimming pool and spa disinfectant in place of chlorine or bromine based products under the name Baquacil.
PHMB is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. It is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.
The PHMB hydrochloride salt (solution) is used in the majority of formulations.
Safety
In 2011, Polyhexamethylenbiguanide was classified as category 2 carcinogen by the European Chemical Agency, but it is still allowed in cosmetics in small quantities if exposure by inhalation is impossible.
See also
References
- ^ "Classification and Labelling of PHMB". European Chemicals Agency.
- S2CID 33172373.
- ^ International Drug Names: Polihexanide
- ^ Maribeth Cousin, Kimberly Restivo, Chelsea Rodriguez, and Justin Lien. USP Antimicrobial Effectiveness Test (GLP). Elkhorn, WI: Geneva Laboratories. 2013. "Archived copy" (PDF). Archived from the original (PDF) on 2016-03-04. Retrieved 2015-04-08.
{{cite web}}
: CS1 maint: archived copy as title (link) - ^ "Nusept". Archived from the original on 2012-03-25. Retrieved 2011-06-08.
- PMID 25710134.