Polysorbate 80

Source: Wikipedia, the free encyclopedia.
Polysorbate 80[1]
A vial containing Polysorbate 80
Names
IUPAC name
Polyoxyethylene (80) sorbitan monooleate
Other names
  • Kolliphor PS 80
  • Montanox 80
  • Alkest TW 80
  • Tween 80
  • PS 80
  • Kotilen-80
Identifiers
ChEMBL
ChemSpider
  • none
ECHA InfoCard
 100.105.529 Edit this at Wikidata
E number E433 (thickeners, ...)
KEGG
RTECS number
  • WG2932500
UNII
Properties
C64H124O26
Molar mass 1310 g/mol
Appearance Amber colored oil
Density 1.102 g/mL
Boiling point > 100°C
100 mL/L[2]
Solubility in other solvents soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene
Viscosity 300–500
centistokes
(@25°C)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Irritant
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
1
0
Flash point 113 °C (235 °F; 386 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Polysorbate 80 is a nonionic

water-soluble
yellow liquid.

Chemistry

Polysorbate 80 is derived from

lipophilic group, in this case, the oleic acid (see polysorbate
for more detail).

The full chemical names for polysorbate 80 are:

  • Polyoxyethylene (80) sorbitan monooleate
  • (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl)

The critical micelle concentration of polysorbate 80 in pure water is reported as 0.012 mM.[3]

Other names

E number: E433

Brand names:

  • Kolliphor PS 80[4] - Kolliphor is a registered trademark of BASF
  • Alkest TW 80
  • Scattics
  • Canarcel
  • Poegasorb 80
  • Montanox 80 – Montanox is a registered trademark of Seppic
  • Tween 80 – Tween is a registered trademark of Croda Americas, Inc.[5]
  • Kotilen-80 - Kotilen is a registered trademark of Kolb AG

Uses

Food

Polysorbate 80 is used as an emulsifier in foods, though research[6] suggests it may "profoundly impact intestinal microbiota in a manner that promotes gut inflammation and associated disease states."

For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.[7] Adding this substance prevents milk proteins from completely coating the fat droplets. This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.

Health and beauty

Polysorbate 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a

cosmetic grade of polysorbate 80 may have more impurities than the food grade.[8]

Medical

Polysorbate 80 is a surfactant and

solubilizer
used in a variety of oral and topical pharmaceutical products.

Polysorbate 80 is an

parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.[9] It is also used as an excipient in some European and Canadian influenza vaccines.[10] Influenza vaccines contain 2.5 μg of polysorbate 80 per dose.[10] Polysorbate 80 is found in many vaccines used in the United States,[11] including the Janssen COVID-19 vaccine.[12] It is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth. It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.[13]

Polysorbate 80 is also used in granulation for stabilization of drugs and excipients when IPA binding.[citation needed]

Laboratory

Some

phenotype of a strain or isolate.[citation needed
]

On RODAC agar plates used in microbiological control, polysorbate 80 counteracts disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow.[citation needed]

See also

  • Polysorbate 20, used as a wetting agent in mouth drops
  • Polysorbate 40
  • Polysorbate 60
    , used as an emulsifier in powdered drink preparations such as hot cocoa mix
  • Polysorbate 65

References

  1. ^ Merck Index, 13th Edition, 7664.
  2. ^ https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Product_Information_Sheet/1/p8466pis.pdf [bare URL PDF]
  3. PMID 15858848
    .
  4. ^ "Polysorbates and Sorbitan Esters for Pharmaceutical Applications". BASF Pharma. Retrieved 2022-06-10.
  5. ^ "Trademark Status & Document Retrieval". tsdr.uspto.gov.
  6. PMID 33752754.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  7. ISSN 0958-6946
    .
  8. ^ "What is Polysorbate 80?". The Honest Company Blog. The Honest Company. Archived from the original on 27 February 2014. Retrieved 24 April 2014.
  9. ^ Gautier & Bellamy. "Pharmaceutical amiodarone composition for parenteral delivery". Archived from the original on 2009-06-20. Retrieved 2008-04-06.
  10. ^ a b Pandemic H1N1 (pH1N1) Influenza Vaccine Quick Reference Guide Archived 2010-10-11 at the Wayback Machine Winnipeg Regional Health Authority 2009
  11. ^ "Vaccine Excipient & Media Summary" (PDF). Centers for Disease Control and Prevention. June 2018.
  12. ^ "Janssen Standing Orders for Covid-19" (PDF).
  13. ^ http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/21371_estrasorb_lbl.pdf [bare URL PDF]

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