Porokeratosis

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Porokeratosis
A porokeratosis lesion in a patient with disseminated superficial actinic porokeratosis.
SpecialtyPediatrics, dermatology Edit this on Wikidata

Porokeratosis is a specific disorder of keratinization that is characterized histologically by the presence of a cornoid lamella, a thin column of closely stacked, parakeratotic cells extending through the

granular layer.[1]
: 532 

Types

Porokeratosis may be divided into the following clinical types:[1]: 532 

Genetics

Linear porokeratosis has been associated with mutations in the PMVK and MVD genes.[7] The PMVK gene encodes the enzyme phosphomevalonate kinase and the MVD gene encodes the enzyme diphosphomevalonate decarboxylase.

Diagnosis

Pathology

Micrograph of a case of porokeratosis showing a characteristic cornoid lamella (dark pink/red structure in the right/upper portion of the image). H&E stain.

Porokeratosis has a characteristic histomorphologic feature known as a cornoid lamella.

Treatment

Dermabrasion

See also

References

  1. ^ .
  2. ^ .
  3. ^ .
  4. ^ a b "Familial disseminated plaque type porokeratosis with multiple horns and squamous cell carcinoma involving anal skin". Archived from the original on 2020-11-26. Retrieved 2013-09-01.
  5. PMID 18685058
    .
  6. .
  7. ^ Atzmony L, Khan HM, Lim YH, Paller AS, Levinsohn JL, Holland KE, Mirza FN, Yin E, Ko CJ, Leventhal JS, Choate KA (2019) Second-Hit, Postzygotic PMVK and MVD Mutations in Linear Porokeratosis. JAMA Dermatol

External links