Portal hypothesis

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The portal hypothesis describes a possible mechanism for some of the health effects of

Later research did not favor the portal hypothesis. It was determined that liver fat accumulation, as opposed to total visceral fat, was correlated with reduced insulin sensitivity and increased VLDL. Additionally, most of the free fatty acids reaching the liver via the portal vein do not originate in visceral fat, rather they are generated largely by abdominal subcutaneous fat. The later adipose tissue expandability hypothesis hypothesizes that the cause of type 2 diabetes is not obesity, but reaching the limit of what an individual's adipose tissue is able to store. This capacity limit varies between individuals and can be very low for people with lipodystrophy.^[2]

References

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