Portal:Medicine

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The Medicine Portal

Santa Maria della Scala
hospital in Siena, Italy

ionizing radiation
, amongst others.

Medicine has been practiced since

cellular and molecular
level in the tissues being stitched arises through science.

Prescientific forms of medicine, now known as traditional medicine or folk medicine, remain commonly used in the absence of scientific medicine and are thus called alternative medicine. Alternative treatments outside of scientific medicine with ethical, safety and efficacy concerns are termed quackery. (Full article...)

Featured articles
are displayed here, which represent some of the best content on English Wikipedia.

  • Image 1 Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction, it is not associated with weight gain and sleepiness, and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue. Bupropion, particularly the immediate release formulation, carries a higher risk of seizure than many other antidepressants, hence caution is recommended in patients with a history of seizure disorder. Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Raised blood pressure is notable. Rare but serious side effects include seizures, liver toxicity, psychosis, and risk of overdose. Bupropion use during pregnancy may be associated with increased odds of congenital heart defects. (Full article...)
    overdose. Bupropion use during pregnancy may be associated with increased odds of congenital heart defects. (Full article...
    )
  • Image 2 Genetics is the study of genes, genetic variation, and heredity in organisms. It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the context of a population. Genetics has given rise to a number of subfields, including molecular genetics, epigenetics and population genetics. Organisms studied within the broad field span the domains of life (archaea, bacteria, and eukarya). (Full article...)
    eukarya). (Full article...
    )
  • Image 3 Anti-FGM road sign near Kapchorwa, Uganda, 2004 Female genital mutilation (FGM) (also known as female genital cutting, female genital mutilation/cutting (FGM/C) and female circumcision) is the ritual cutting or removal of some or all of the vulva. The practice is found in some countries of Africa, Asia and the Middle East, and within their respective diasporas. , UNICEF estimates that "at least 200 million girls... in 31 countries"—including Indonesia, Iraq, Yemen, and 27 African countries including Egypt—had been subjected to one or more types of FGM. Typically carried out by a traditional circumciser using a blade, FGM is conducted from days after birth to puberty and beyond. In half of the countries for which national statistics are available, most girls are cut before the age of five. Procedures differ according to the country or ethnic group. They include removal of the clitoral hood (type 1-a) and clitoral glans (1-b); removal of the inner labia (2-a); and removal of the inner and outer labia and closure of the vulva (type 3). In this last procedure, known as infibulation, a small hole is left for the passage of urine and menstrual fluid; the vagina is opened for intercourse and opened further for childbirth. The practice is rooted in gender inequality, attempts to control women's sexuality, and ideas about purity, modesty, and beauty. It is usually initiated and carried out by women, who see it as a source of honour, and who fear that failing to have their daughters and granddaughters cut will expose the girls to social exclusion. Adverse health effects depend on the type of procedure; they can include recurrent infections, difficulty urinating and passing menstrual flow, chronic pain, the development of cysts, an inability to get pregnant, complications during childbirth, and fatal bleeding. There are no known health benefits. (Full article...)

    clitoral glans (1-b); removal of the inner labia (2-a); and removal of the inner and outer labia and closure of the vulva (type 3). In this last procedure, known as infibulation, a small hole is left for the passage of urine and menstrual fluid; the vagina is opened for intercourse and opened further for childbirth. The practice is rooted in gender inequality, attempts to control women's sexuality, and ideas about purity, modesty, and beauty. It is usually initiated and carried out by women, who see it as a source of honour, and who fear that failing to have their daughters and granddaughters cut will expose the girls to social exclusion. Adverse health effects depend on the type of procedure; they can include recurrent infections, difficulty urinating and passing menstrual flow, chronic pain, the development of cysts, an inability to get pregnant, complications during childbirth, and fatal bleeding. There are no known health benefits. (Full article...
    )
  • Image 4 Typical rash seen in dengue fever Dengue fever is a mosquito-borne tropical disease caused by dengue virus. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14 days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin itching and skin rash. Recovery generally takes two to seven days. In a small proportion of cases, the disease develops into severe dengue (previously known as dengue hemorrhagic fever or dengue shock syndrome) with bleeding, low levels of blood platelets, blood plasma leakage, and dangerously low blood pressure. Dengue virus has four confirmed serotypes; infection with one type usually gives lifelong immunity to that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications. The symptoms of dengue resemble many other diseases including malaria, influenza, and Zika. Blood tests are available to confirm the diagnosis including detecting viral RNA, or antibodies to the virus. (Full article...)

    antibodies to the virus. (Full article...
    )
  • Image 5 Tatsuguchi soon after his induction into the Imperial Japanese Army in 1941 and his initial assignment to the First Imperial Guard Regiment in Tokyo Paul Nobuo Tatsuguchi (辰口 信夫, Tatsuguchi Nobuo), sometimes mistakenly referred to as Nebu Tatsuguchi (August 31, 1911 – May 30, 1943), was a Japanese soldier and surgeon who served in the Imperial Japanese Army (IJA) during World War II. He was killed during the Battle of Attu on Attu Island, Alaska, United States, on May 30, 1943. A devout Seventh-day Adventist, Tatsuguchi studied medicine and was licensed as a physician in the United States (US). He returned to his native Japan to practice medicine at the Tokyo Adventist Sanitarium, where he received further medical training. In 1941, he was ordered to cease his medical practice and conscripted into the IJA as an acting medical officer, although he was given an enlisted rather than officer rank because of his American connections. In late 1942, Tatsuguchi was sent to Attu, which had been occupied by Japanese forces in June 1942. On May 11, 1943, The United States Army landed on the island, intending to retake American soil from the Japanese. (Full article...)

    Tatsuguchi soon after his induction into the Imperial Japanese Army in 1941 and his initial assignment to the First Imperial Guard Regiment in Tokyo
    Paul Nobuo Tatsuguchi (辰口 信夫, Tatsuguchi Nobuo), sometimes mistakenly referred to as Nebu Tatsuguchi (August 31, 1911 – May 30, 1943), was a Japanese soldier and surgeon who served in the Imperial Japanese Army (IJA) during World War II. He was killed during the Battle of Attu on Attu Island, Alaska, United States, on May 30, 1943.

    A devout Seventh-day Adventist, Tatsuguchi studied medicine and was licensed as a physician in the United States (US). He returned to his native Japan to practice medicine at the Tokyo Adventist Sanitarium, where he received further medical training. In 1941, he was ordered to cease his medical practice and conscripted into the IJA as an acting medical officer, although he was given an enlisted rather than officer rank because of his American connections. In late 1942, Tatsuguchi was sent to Attu, which had been occupied by Japanese forces in June 1942. On May 11, 1943, The United States Army landed on the island, intending to retake American soil from the Japanese. (Full article...)
  • Image 6 A CBC specimen in front of a printout displaying CBC and differential results A complete blood count (CBC), also known as a full blood count (FBC), is a set of medical laboratory tests that provide information about the cells in a person's blood. The CBC indicates the counts of white blood cells, red blood cells and platelets, the concentration of hemoglobin, and the hematocrit (the volume percentage of red blood cells). The red blood cell indices, which indicate the average size and hemoglobin content of red blood cells, are also reported, and a white blood cell differential, which counts the different types of white blood cells, may be included. The CBC is often carried out as part of a medical assessment and can be used to monitor health or diagnose diseases. The results are interpreted by comparing them to reference ranges, which vary with sex and age. Conditions like anemia and thrombocytopenia are defined by abnormal complete blood count results. The red blood cell indices can provide information about the cause of a person's anemia such as iron deficiency and vitamin B12 deficiency, and the results of the white blood cell differential can help to diagnose viral, bacterial and parasitic infections and blood disorders like leukemia. Not all results falling outside of the reference range require medical intervention. (Full article...)

    blood disorders like leukemia. Not all results falling outside of the reference range require medical intervention. (Full article...
    )
  • Image 7 Photomicrograph of Giemsa-stained Trypanosoma cruzi trypomastigotes in human blood Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by Trypanosoma cruzi. It is spread mostly by insects in the subfamily Triatominae, known as "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or swelling at the site of the bite. After four to eight weeks, untreated individuals enter the chronic phase of disease, which in most cases does not result in further symptoms. Up to 45% of people with chronic infections develop heart disease 10–30 years after the initial illness, which can lead to heart failure. Digestive complications, including an enlarged esophagus or an enlarged colon, may also occur in up to 21% of people, and up to 10% of people may experience nerve damage. T. cruzi is commonly spread to humans and other mammals by the kissing bug's bite wound and infected feces. The disease may also be spread through blood transfusion, organ transplantation, consuming food or drink contaminated with the parasites, and vertical transmission (from a mother to her baby). Diagnosis of early disease is by finding the parasite in the blood using a microscope or detecting its DNA by polymerase chain reaction. Chronic disease is diagnosed by finding antibodies for T. cruzi in the blood. (Full article...)

    DNA by polymerase chain reaction. Chronic disease is diagnosed by finding antibodies for T. cruzi in the blood. (Full article...
    )
  • Image 8 Major General Rupert Major Downes, CMG, KStJ, VD, FRACS (10 February 1885 – 5 March 1945) was an Australian soldier, surgeon and historian. The son of British Army officer Major Francis Downes, Downes joined the Army as a trumpeter while he was still at school. He attended the University of Melbourne, graduating with his medical degrees in 1907 and a Doctor of Medicine degree in 1911. He was commissioned as a captain in the Australian Army Medical Corps in 1908, and after the outbreak of the First World War he joined the First Australian Imperial Force (AIF) in 1914 as its youngest lieutenant colonel. He served in the Gallipoli campaign, and was appointed Assistant Director of Medical Services (ADMS) of the newly formed Anzac Mounted Division in 1916, which he combined with the post of ADMS AIF Egypt. In 1917, he became Deputy Director of Medical Services (DDMS) of the Desert Mounted Corps. After the war, he wrote articles on medical aspects of the Sinai and Palestine campaign, and the section on the campaign for the Official History of Australia in the War of 1914–1918. (Full article...)
    Anzac Mounted Division in 1916, which he combined with the post of ADMS AIF Egypt. In 1917, he became Deputy Director of Medical Services (DDMS) of the Desert Mounted Corps. After the war, he wrote articles on medical aspects of the Sinai and Palestine campaign, and the section on the campaign for the Official History of Australia in the War of 1914–1918. (Full article...
    )
  • Image 9 CT scan of the brain showing subarachnoid hemorrhage as a white area in the center (marked by the arrow) and stretching into the sulci to either side Subarachnoid hemorrhage (SAH) is bleeding into the subarachnoid space—the area between the arachnoid membrane and the pia mater surrounding the brain. Symptoms may include a severe headache of rapid onset, vomiting, decreased level of consciousness, fever, weakness, numbness, and sometimes seizures. Neck stiffness or neck pain are also relatively common. In about a quarter of people a small bleed with resolving symptoms occurs within a month of a larger bleed. SAH may occur as a result of a head injury or spontaneously, usually from a ruptured cerebral aneurysm. Risk factors for spontaneous cases include high blood pressure, smoking, family history, alcoholism, and cocaine use. Generally, the diagnosis can be determined by a CT scan of the head if done within six hours of symptom onset. Occasionally, a lumbar puncture is also required. After confirmation further tests are usually performed to determine the underlying cause. (Full article...)

    CT scan of the head if done within six hours of symptom onset. Occasionally, a lumbar puncture is also required. After confirmation further tests are usually performed to determine the underlying cause. (Full article...
    )
  • Image 10 Race Against Time: Searching for Hope in AIDS-Ravaged Africa is a non-fiction book written by Stephen Lewis for the Massey Lectures. Lewis wrote it in early to mid-2005 and House of Anansi Press released it as a corresponding lecture series began in October 2005. Each of the book's chapters were delivered as a different lecture in a different Canadian city, beginning in Vancouver on October 18 and ending in Toronto on October 28. The speeches were aired on CBC Radio One between November 7 and 11. The author and orator, Stephen Lewis, was at that time the United Nations Special Envoy for HIV/AIDS in Africa and former Canadian ambassador to the United Nations. Although he wrote the book and lectures in his role as a concerned Canadian citizen, his criticism of the United Nations (UN), international organizations, and other diplomats, including naming specific people, was called undiplomatic and led several reviewers to speculate whether he would be removed from his UN position. In the book and the lectures, Lewis argues that significant changes are required to meet the Millennium Development Goals in Africa by their 2015 deadline. Lewis explains the historical context of Africa since the 1980s, citing a succession of disastrous economic policies by international financial institutions that contributed to, rather than reduced, poverty. He connects the structural adjustment loans, with conditions of limited public spending on health and education infrastructure, to the uncontrolled spread of AIDS and subsequent food shortages as the disease infected much of the working-age population. Lewis also addresses such issues as discrimination against women and primary education for children. To help alleviate problems, he ends with potential solutions which mainly require increased funding by G8 countries to levels beyond what they promise. (Full article...)
    structural adjustment loans, with conditions of limited public spending on health and education infrastructure, to the uncontrolled spread of AIDS and subsequent food shortages as the disease infected much of the working-age population. Lewis also addresses such issues as discrimination against women and primary education for children. To help alleviate problems, he ends with potential solutions which mainly require increased funding by G8 countries to levels beyond what they promise. (Full article...
    )
  • Image 11 Biopsy of small bowel showing coeliac disease manifested by blunting of villi, crypt hypertrophy, and lymphocyte infiltration of crypts Coeliac disease (British English) or celiac disease (American English) is a long-term autoimmune disorder, primarily affecting the small intestine, where individuals develop intolerance to gluten, present in foods such as wheat, rye and barley. Classic symptoms include gastrointestinal problems such as chronic diarrhoea, abdominal distention, malabsorption, loss of appetite, and among children failure to grow normally. Non-classic symptoms are more common, especially in people older than two years. There may be mild or absent gastrointestinal symptoms, a wide number of symptoms involving any part of the body, or no obvious symptoms. Coeliac disease was first described in childhood; however, it may develop at any age. It is associated with other autoimmune diseases, such as Type 1 diabetes mellitus and Hashimoto's thyroiditis, among others. Coeliac disease is caused by a reaction to gluten, a group of various proteins found in wheat and in other grains such as barley and rye. Moderate quantities of oats, free of contamination with other gluten-containing grains, are usually tolerated. The occurrence of problems may depend on the variety of oat. It occurs more often in people who are genetically predisposed. Upon exposure to gluten, an abnormal immune response may lead to the production of several different autoantibodies that can affect a number of different organs. In the small bowel, this causes an inflammatory reaction and may produce shortening of the villi lining the small intestine (villous atrophy). This affects the absorption of nutrients, frequently leading to anaemia. (Full article...)
  • Image 12 Diagram showing the position of the pancreas, behind the stomach (which is transparent in this schematic). Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. These cancerous cells have the ability to invade other parts of the body. A number of types of pancreatic cancer are known. The most common, pancreatic adenocarcinoma, accounts for about 90% of cases, and the term "pancreatic cancer" is sometimes used to refer only to that type. These adenocarcinomas start within the part of the pancreas that makes digestive enzymes. Several other types of cancer, which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells. (Full article...)

    ability to invade other parts of the body. A number of types of pancreatic cancer are known.

    The most common, pancreatic adenocarcinoma, accounts for about 90% of cases, and the term "pancreatic cancer" is sometimes used to refer only to that type. These adenocarcinomas start within the part of the pancreas that makes digestive enzymes. Several other types of cancer, which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells. (Full article...
    )
  • Image 13 White in 1989 Ryan Wayne White (December 6, 1971 – April 8, 1990) was an American teenager from Kokomo, Indiana, who became a national poster child for HIV/AIDS in the United States after his school barred him from attending classes following a diagnosis of AIDS. As a haemophiliac, he became infected with HIV from a contaminated factor VIII blood treatment and, when diagnosed in December 1984, was given six months to live. Doctors said he posed no risk to other students, as AIDS is not an airborne disease and spreads solely through bodily fluids, but AIDS was poorly understood by the general public at the time. When White tried to return to school, many parents and teachers in Howard County rallied against his attendance due to unwarranted concerns of the disease spreading to other students and staff. A lengthy administrative appeal process ensued, and news of the conflict turned White into a popular celebrity and advocate for AIDS research and public education. Surprising his doctors, White lived five years longer than predicted. He died on April 8, 1990, one month before his high school graduation. (Full article...)

    White in 1989

    Ryan Wayne White (December 6, 1971 – April 8, 1990) was an American teenager from Kokomo, Indiana, who became a national poster child for HIV/AIDS in the United States after his school barred him from attending classes following a diagnosis of AIDS.

    As a haemophiliac, he became infected with HIV from a contaminated factor VIII blood treatment and, when diagnosed in December 1984, was given six months to live. Doctors said he posed no risk to other students, as AIDS is not an airborne disease and spreads solely through bodily fluids, but AIDS was poorly understood by the general public at the time. When White tried to return to school, many parents and teachers in Howard County rallied against his attendance due to unwarranted concerns of the disease spreading to other students and staff. A lengthy administrative appeal process ensued, and news of the conflict turned White into a popular celebrity and advocate for AIDS research and public education. Surprising his doctors, White lived five years longer than predicted. He died on April 8, 1990, one month before his high school graduation. (Full article...)
  • Image 14 Dark Archives: A Librarian's Investigation into the Science and History of Books Bound in Human Skin is a 2020 non-fiction book by the medical librarian and death-positive advocate Megan Rosenbloom. Dealing with anthropodermic bibliopegy, the binding of books in human skin, it expounds upon Rosenbloom's research on such books and their historical, ethical, and cultural implications. The book focuses on the relationship between anthropodermic bibliopegy and the history of medicine; most confirmed cases of such books were created or owned by medical professionals, in contrast to common stereotypes that they were associated with Nazi Germany, serial killers, or the French Revolution. Rosenbloom discusses how the practice reflects the changing attitudes towards consent, ownership, and disposal of human bodies, and how the history of anthropodermic books intertwines with the history of medical ethics as a field. She interviews librarians, archivists, collectors, and experts on the topic, and examines notable examples of such books and their origins. Though Rosenbloom supports the preservation and maintenance of anthropodermic books, Dark Archives also covers arguments to the contrary, such as those espoused by Princeton University Library senior librarian Paul Needham. (Full article...)
    death-positive advocate Megan Rosenbloom. Dealing with anthropodermic bibliopegy, the binding of books in human skin, it expounds upon Rosenbloom's research on such books and their historical, ethical, and cultural implications.

    The book focuses on the relationship between anthropodermic bibliopegy and the history of medicine; most confirmed cases of such books were created or owned by medical professionals, in contrast to common stereotypes that they were associated with Nazi Germany, serial killers, or the French Revolution. Rosenbloom discusses how the practice reflects the changing attitudes towards consent, ownership, and disposal of human bodies, and how the history of anthropodermic books intertwines with the history of medical ethics as a field. She interviews librarians, archivists, collectors, and experts on the topic, and examines notable examples of such books and their origins. Though Rosenbloom supports the preservation and maintenance of anthropodermic books, Dark Archives also covers arguments to the contrary, such as those espoused by Princeton University Library senior librarian Paul Needham. (Full article...
    )
  • Image 15 Thyrotoxic periodic paralysis occurs when the thyroid gland releases excessive amounts of thyroxine (thyroid hormone). Thyrotoxic periodic paralysis (TPP) is a rare condition featuring attacks of muscle weakness in the presence of hyperthyroidism (overactivity of the thyroid gland). Hypokalemia (a decreased potassium level in the blood) is usually present during attacks. The condition may be life-threatening if weakness of the breathing muscles leads to respiratory failure, or if the low potassium levels lead to abnormal heart rhythms. If untreated, it is typically recurrent in nature. The condition has been linked with genetic mutations in genes that code for certain ion channels that transport electrolytes (sodium and potassium) across cell membranes. The main ones are the L-type calcium channel α1-subunit and potassium inward rectifier 2.6; it is therefore classified as a channelopathy. The abnormality in the channel is thought to lead to shifts of potassium into cells, under conditions of high thyroxine (thyroid hormone) levels, usually with an additional precipitant. (Full article...)

    thyroxine (thyroid hormone) levels, usually with an additional precipitant. (Full article...
    )

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  • Image 1 Characteristic lip telangiectases. Hereditary hemorrhagic telangiectasia (HHT), also known as Osler–Weber–Rendu disease and Osler–Weber–Rendu syndrome, is a rare autosomal dominant genetic disorder that leads to abnormal blood vessel formation in the skin, mucous membranes, and often in organs such as the lungs, liver, and brain. It may lead to nosebleeds, acute and chronic digestive tract bleeding, and various problems due to the involvement of other organs. Treatment focuses on reducing bleeding from blood vessel lesions, and sometimes surgery or other targeted interventions to remove arteriovenous malformations in organs. Chronic bleeding often requires iron supplements and sometimes blood transfusions. HHT is transmitted in an autosomal dominant fashion, and occurs in one in 5,000–8,000 people in North America. (Full article...)

    iron supplements and sometimes blood transfusions. HHT is transmitted in an autosomal dominant fashion, and occurs in one in 5,000–8,000 people in North America. (Full article...
    )
  • Image 2 Centers for Disease Control and Prevention (CDC) recommendations for the amount of sleep needed decrease with age. While sleep quantity is important, good sleep quality is also essential to avoid sleep disorders. Sleep hygiene is a behavioral and environmental practice developed in the late 1970s as a method to help people with mild to moderate insomnia. Clinicians assess the sleep hygiene of people with insomnia and other conditions, such as depression, and offer recommendations based on the assessment. Sleep hygiene recommendations include: establishing a regular sleep schedule; using naps with care; not exercising physically or mentally too close to bedtime; limiting worry; limiting exposure to light in the hours before sleep; getting out of bed if sleep does not come; not using bed for anything but sleep and sex; avoiding alcohol as well as nicotine, caffeine, and other stimulants in the hours before bedtime; and having a peaceful, comfortable and dark sleep environment. However, , the empirical evidence for the effectiveness of sleep hygiene is "limited and inconclusive" for the general population and for the treatment of insomnia, despite being the oldest treatment for insomnia. A systematic review by the AASM concluded that clinicians should not prescribe sleep hygiene for insomnia due to the evidence of absence of its efficacy and potential delaying of adequate treatment, recommending instead that effective therapies such as CBT-i should be preferred. (Full article...)
    Centers for Disease Control and Prevention (CDC) recommendations for the amount of sleep needed decrease with age. While sleep quantity is important, good sleep quality is also essential to avoid sleep disorders.

    Sleep hygiene is a behavioral and environmental practice developed in the late 1970s as a method to help people with mild to moderate insomnia. Clinicians assess the sleep hygiene of people with insomnia and other conditions, such as depression, and offer recommendations based on the assessment. Sleep hygiene recommendations include: establishing a regular sleep schedule; using naps with care; not exercising physically or mentally too close to bedtime; limiting worry; limiting exposure to light in the hours before sleep; getting out of bed if sleep does not come; not using bed for anything but sleep and sex; avoiding alcohol as well as nicotine, caffeine, and other stimulants in the hours before bedtime; and having a peaceful, comfortable and dark sleep environment. However, , the empirical evidence for the effectiveness of sleep hygiene is "limited and inconclusive" for the general population and for the treatment of insomnia, despite being the oldest treatment for insomnia. A systematic review by the AASM concluded that clinicians should not prescribe sleep hygiene for insomnia due to the evidence of absence of its efficacy and potential delaying of adequate treatment, recommending instead that effective therapies such as CBT-i should be preferred. (Full article...)
  • Image 3 Dorothy P. Rice (June 11, 1922 – February 25, 2017) was an American health statistician whose work contributed to the creation of Medicare in the United States. Rice graduated from the University of Wisconsin–Madison and began working with the US government soon after, but left the workforce to begin raising a child. Just over a decade later, she returned to government work with a position at the Social Security Administration, where she was one of the first scientists to study the economic cost of illness and exposed a lack of health insurance among the elderly. Rice was later the director of the National Center for Health Statistics from 1976 to 1982, where she helped create the National Death Index. She finished her career at the University of California, San Francisco, where she was a Regents' lecturer and professor emeritus. During her time at the university, she co-authored a paper on the costs of smoking, which impacted ongoing legal negotiations between the US government and the US tobacco industry and contributed to the Tobacco Master Settlement Agreement. (Full article...)
    health statistician whose work contributed to the creation of Medicare in the United States. Rice graduated from the University of Wisconsin–Madison and began working with the US government soon after, but left the workforce to begin raising a child. Just over a decade later, she returned to government work with a position at the Social Security Administration, where she was one of the first scientists to study the economic cost of illness and exposed a lack of health insurance among the elderly.

    Rice was later the director of the National Center for Health Statistics from 1976 to 1982, where she helped create the National Death Index. She finished her career at the University of California, San Francisco, where she was a Regents' lecturer and professor emeritus. During her time at the university, she co-authored a paper on the costs of smoking, which impacted ongoing legal negotiations between the US government and the US tobacco industry and contributed to the Tobacco Master Settlement Agreement. (Full article...
    )
  • Image 4 Irving Isadore Gottesman (December 29, 1930 – June 29, 2016) was an American professor of psychology who devoted most of his career to the study of the genetics of schizophrenia. He wrote 17 books and more than 290 other publications, mostly on schizophrenia and behavioral genetics, and created the first academic program on behavioral genetics in the United States. He won awards such as the Hofheimer Prize for Research, the highest award from the American Psychiatric Association for psychiatric research. Lastly, Gottesman was a professor in the psychology department at the University of Minnesota, where he received his Ph.D. A native of Ohio, Gottesman studied psychology for his undergraduate and graduate degrees, became a faculty member at various universities, and spent most of his career at the University of Virginia and the University of Minnesota. He is known for researching schizophrenia in identical twins to document the contributions of genetics and the family, social, cultural, and economic environment to the onset, progress, and inter-generational transmission of the disorder. Gottesman has worked with researchers to analyze hospital records and conduct follow-up interviews of twins where one or both were schizophrenic. He has also researched the effects of genetics and the environment on human violence and variations in human intelligence. Gottesman and co-researcher James Shields introduced the word epigenetics—the control of genes by biochemical signals modified by the environment from other parts of the genome—to the field of psychiatric genetics. (Full article...)
    behavioral genetics, and created the first academic program on behavioral genetics in the United States. He won awards such as the Hofheimer Prize for Research, the highest award from the American Psychiatric Association for psychiatric research. Lastly, Gottesman was a professor in the psychology department at the University of Minnesota, where he received his Ph.D.

    A native of Ohio, Gottesman studied psychology for his undergraduate and graduate degrees, became a faculty member at various universities, and spent most of his career at the University of Virginia and the University of Minnesota. He is known for researching schizophrenia in identical twins to document the contributions of genetics and the family, social, cultural, and economic environment to the onset, progress, and inter-generational transmission of the disorder. Gottesman has worked with researchers to analyze hospital records and conduct follow-up interviews of twins where one or both were schizophrenic. He has also researched the effects of genetics and the environment on human violence and variations in human intelligence. Gottesman and co-researcher James Shields introduced the word epigenetics—the control of genes by biochemical signals modified by the environment from other parts of the genome—to the field of psychiatric genetics. (Full article...
    )
  • Image 5 The Xinxiu bencao (Chinese: 新修本草; pinyin: Xīnxiū běncǎo), also known as the Tang bencao (Chinese: 唐本草; pinyin: Táng běncǎo), is a Chinese pharmacopoeia written in the Tang dynasty by a team of officials and physicians headed by editor-in-chief Su Jing [zh]. It borrowed heavily from—and expanded upon—an earlier monograph by Tao Hongjing. The text was first published in 659; although it is now considered lost in China, at least one copy exists in Japan, where the text had been transmitted to in 721. (Full article...)
    The Xinxiu bencao (Chinese: 新修本草; pinyin: Xīnxiū běncǎo), also known as the Tang bencao (Chinese: 唐本草; pinyin: Táng běncǎo), is a Chinese pharmacopoeia written in the Tang dynasty by a team of officials and physicians headed by editor-in-chief Su Jing [zh]. It borrowed heavily from—and expanded upon—an earlier monograph by Tao Hongjing. The text was first published in 659; although it is now considered lost in China, at least one copy exists in Japan, where the text had been transmitted to in 721. (Full article...)
  • Image 6 Pantothenic acid (vitamin B5) is a B vitamin and an essential nutrient. All animals need pantothenic acid in order to synthesize coenzyme A (CoA), which is essential for cellular energy production and for the synthesis and degradation of proteins, carbohydrates, and fats. Pantothenic acid is the combination of pantoic acid and β-alanine. Its name comes from the Greek πάντοθεν pantothen, meaning "from everywhere", because pantothenic acid, at least in small amounts, is in almost all foods. Deficiency of pantothenic acid is very rare in humans. In dietary supplements and animal feed, the form commonly used is calcium pantothenate, because chemically it is more stable, and hence makes for longer product shelf-life, than sodium pantothenate and free pantothenic acid. (Full article...)
    β-alanine. Its name comes from the Greek πάντοθεν pantothen, meaning "from everywhere", because pantothenic acid, at least in small amounts, is in almost all foods. Deficiency of pantothenic acid is very rare in humans. In dietary supplements and animal feed, the form commonly used is calcium pantothenate, because chemically it is more stable, and hence makes for longer product shelf-life, than sodium pantothenate and free pantothenic acid. (Full article...
    )
  • Image 7 The abortion–breast cancer hypothesis posits that having an induced abortion can increase the risk of getting breast cancer. This hypothesis is at odds with mainstream scientific opinion and is rejected by major medical professional organizations; despite this, it continues to be widely propagated as pseudoscience, typically in service of an anti-abortion agenda. In early pregnancy, hormone levels increase, leading to breast growth. The hypothesis proposes that if this process is altered by an abortion, then more immature cells could be left behind, and that these immature cells could increase the risk of breast cancer over time. (Full article...)
    The
    anti-abortion agenda.

    In early pregnancy, hormone levels increase, leading to breast growth. The hypothesis proposes that if this process is altered by an abortion, then more immature cells could be left behind, and that these immature cells could increase the risk of breast cancer over time. (Full article...
    )
  • Image 8 Scanning electron micrograph of HIV-1 (in green) budding from cultured lymphocyte. Multiple round bumps on cell surface represent sites of assembly and budding of virions. The human immunodeficiency viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, the average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. In most cases, HIV is a sexually transmitted infection and occurs by contact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids. Non-sexual transmission can occur from an infected mother to her infant during pregnancy, during childbirth by exposure to her blood or vaginal fluid, and through breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. Research has shown (for both same-sex and opposite-sex couples) that HIV is untransmittable through condomless sexual intercourse if the HIV-positive partner has a consistently undetectable viral load. (Full article...)

    acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, the average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype.

    In most cases, HIV is a sexually transmitted infection and occurs by contact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids. Non-sexual transmission can occur from an infected mother to her infant during pregnancy, during childbirth by exposure to her blood or vaginal fluid, and through breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.
    Research has shown (for both same-sex and opposite-sex couples) that HIV is untransmittable through condomless sexual intercourse if the HIV-positive partner has a consistently undetectable viral load. (Full article...
    )
  • Image 9 Wittman around 1880, by Albert Londe Marie "Blanche" Wittman (often spelled Wittmann; April 15, 1859 – 1913) was a French woman known as one of the hysteria patients of Jean-Martin Charcot. She was institutionalized in La Salpêtrière in 1877, and was treated by Charcot until his death in 1893. She later became a radiology assistant at the hospital, which resulted in amputations of her arms due to radiation poisoning. Charcot's techniques were controversial; commentators have disagreed as to whether Wittman suffered from a physical condition like epileptic seizures, suffered from mass hysteria resulting from conditions at La Salpêtrière, or was merely feigning symptoms. She is depicted in A Clinical Lesson at the Salpêtrière (1887) and was the subject of a 2004 Per Olov Enquist novel. (Full article...)

    radiation poisoning.

    Charcot's techniques were controversial; commentators have disagreed as to whether Wittman suffered from a physical condition like epileptic seizures, suffered from mass hysteria resulting from conditions at La Salpêtrière, or was merely feigning symptoms. She is depicted in A Clinical Lesson at the Salpêtrière (1887) and was the subject of a 2004 Per Olov Enquist novel. (Full article...
    )
  • Image 10 Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often in the back along with muscle weakness, beginning in the feet and hands, often spreading to the arms and upper body. The symptoms may develop over hours to a few weeks. During the acute phase, the disorder can be life-threatening, with about 15% of people developing weakness of the breathing muscles and, therefore, requiring mechanical ventilation. Some are affected by changes in the function of the autonomic nervous system, which can lead to dangerous abnormalities in heart rate and blood pressure. Although the cause is unknown, the underlying mechanism involves an autoimmune disorder in which the body's immune system mistakenly attacks the peripheral nerves and damages their myelin insulation. Sometimes this immune dysfunction is triggered by an infection or, less commonly, by surgery, and rarely, by vaccination. The diagnosis is usually based on the signs and symptoms through the exclusion of alternative causes and supported by tests such as nerve conduction studies and examination of the cerebrospinal fluid. There are a number of subtypes based on the areas of weakness, results of nerve conduction studies, and the presence of certain antibodies. It is classified as an acute polyneuropathy. (Full article...)
    autoimmune disorder in which the body's immune system mistakenly attacks the peripheral nerves and damages their myelin insulation. Sometimes this immune dysfunction is triggered by an infection or, less commonly, by surgery, and rarely, by vaccination. The diagnosis is usually based on the signs and symptoms through the exclusion of alternative causes and supported by tests such as nerve conduction studies and examination of the cerebrospinal fluid. There are a number of subtypes based on the areas of weakness, results of nerve conduction studies, and the presence of certain antibodies. It is classified as an acute polyneuropathy. (Full article...
    )
  • Image 11 Melioidosis abscess on the abdomen Melioidosis is an infectious disease caused by a gram-negative bacterium called Burkholderia pseudomallei. Most people exposed to B. pseudomallei experience no symptoms; however, those who do experience symptoms have signs and symptoms that range from mild, such as fever and skin changes, to severe with pneumonia, abscesses, and septic shock that could cause death. Approximately 10% of people with melioidosis develop symptoms that last longer than two months, termed "chronic melioidosis". Humans are infected with B. pseudomallei by contact with contaminated soil or water. The bacteria enter the body through wounds, inhalation, or ingestion. Person-to-person or animal-to-human transmission is extremely rare. The infection is constantly present in Southeast Asia particularly in northeast Thailand and northern Australia. In temperate countries such as Europe and the United States, melioidosis cases are usually imported from countries where melioidosis is endemic. The signs and symptoms of melioidosis resemble tuberculosis and misdiagnosis is common. Diagnosis is usually confirmed by the growth of B. pseudomallei from an infected person's blood or other bodily fluid such as pus, sputum, and urine. Those with melioidosis are treated first with an "intensive phase" course of intravenous antibiotics (most commonly ceftazidime) followed by a several-month treatment course of co-trimoxazole. In countries with the advanced healthcare system, approximately 10% of people with melioidosis die from the disease. In less developed countries, the death rate could reach 40%. (Full article...)

    co-trimoxazole. In countries with the advanced healthcare system, approximately 10% of people with melioidosis die from the disease. In less developed countries, the death rate could reach 40%. (Full article...
    )
  • Image 12 The Compatibility Gene is a 2013 book about the discovery of the mechanism of compatibility in the human immune system by the English professor of immunology, Daniel M. Davis. It describes the history of immunology with the discovery of the principle of graft rejection by Peter Medawar in the 1950s, and the way the body distinguishes self from not-self via natural killer cells. The compatibility mechanism contributes also to the success of pregnancy by helping the placenta to form, and may play a role in mate selection. (Full article...)
    graft rejection by Peter Medawar in the 1950s, and the way the body distinguishes self from not-self via natural killer cells. The compatibility mechanism contributes also to the success of pregnancy by helping the placenta to form, and may play a role in mate selection. (Full article...
    )
  • Image 13 TEM micrograph of poliovirus virions. Scale bar (white): 50 nm Poliovirus, the causative agent of polio (also known as poliomyelitis), is a serotype of the species Enterovirus C, in the family of Picornaviridae. There are three poliovirus serotypes: types 1, 2, and 3. Poliovirus is composed of an RNA genome and a protein capsid. The genome is a single-stranded positive-sense RNA (+ssRNA) genome that is about 7500 nucleotides long. The viral particle is about 30 nm in diameter with icosahedral symmetry. Because of its short genome and its simple composition—only RNA and a nonenveloped icosahedral protein coat that encapsulates it—poliovirus is widely regarded as the simplest significant virus. (Full article...)

    single-stranded positive-sense RNA (+ssRNA) genome that is about 7500 nucleotides long. The viral particle is about 30 nm in diameter with icosahedral symmetry. Because of its short genome and its simple composition—only RNA and a nonenveloped icosahedral protein coat that encapsulates it—poliovirus is widely regarded as the simplest significant virus. (Full article...
    )
  • Image 14 Sir John Struthers MD FRCSE FRSE ((1823-02-21)21 February 1823 – (1899-02-24)24 February 1899) was the first Regius Professor of Anatomy at the University of Aberdeen. He was a dynamic teacher and administrator, transforming the status of the institutions in which he worked. He was equally passionate about anatomy, enthusiastically seeking out and dissecting the largest and finest specimens, including whales, and troubling his colleagues with his single-minded quest for money and space for his collection. His collection was donated to Surgeon's Hall in Edinburgh. Among scientists, he is perhaps best known for his work on the ligament which bears his name. His work on the rare and vestigial ligament of Struthers came to the attention of Charles Darwin, who used it in his Descent of Man to help argue the case that man and other mammals shared a common ancestor ; or "community of descent," as Darwin expressed it. (Full article...)
    common ancestor ; or "community of descent," as Darwin expressed it. (Full article...
    )
  • Image 15 Body image disturbance (BID) is a common symptom in patients with eating disorders and is characterized by an altered perception of one's own body. The onset is mainly attributed to patients with anorexia nervosa who persistently tend to subjectively discern themselves as average or overweight despite adequate, clinical grounds for a classification of being considerably or severely underweight. The symptom is an altered perception of one's body and a severe state of bodily dissatisfaction characterizing the body image disturbance. It is included among the diagnostic criteria for anorexia nervosa in DSM-5 (criterion C). (Full article...)
    Body image disturbance (BID) is a common symptom in patients with eating disorders and is characterized by an altered perception of one's own body.

    The onset is mainly attributed to patients with anorexia nervosa who persistently tend to subjectively discern themselves as average or overweight despite adequate, clinical grounds for a classification of being considerably or severely underweight. The symptom is an altered perception of one's body and a severe state of bodily dissatisfaction characterizing the body image disturbance. It is included among the diagnostic criteria for anorexia nervosa in DSM-5 (criterion C). (Full article...)

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