Pozanicline

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Pozanicline
Identifiers
  • 2-Methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine
JSmol)
  • CC1=C(C=CC=N1)OC[C@@H]2CCCN2
  • InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1 ☒N
  • Key:YRVIKLBSVVNSHF-JTQLQIEISA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Pozanicline (

α3β4 subtypes familiar to nicotine. It has particularly low tendency to cause side effects compared to other drugs in the class.[9][10]

Synthesis

Pozanicline is synthesized from 2-methyl-3-hydroxypyridine and Boc-L-Prolinol through a dehydration reaction followed by deprotection of the nitrogen atom of prolinol[11]

References

  1. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 62" (PDF). World Health Organization. p. 257. Archived (PDF) from the original on 18 May 2016. Retrieved 3 January 2017.
  2. PMID 9022806
    .
  3. PMID 9336329
    .
  4. PMID 9336330
    .
  5. S2CID 20080069
    .
  6. S2CID 24951969
    .
  7. PMID 19481067
    .
  8. PMID 19555668
    .
  9. PMID 15179445
    .
  10. PMID 17689498
    .
  11. PMID 15179445
    .
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