Prazepam
Clinical data | |
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Other names | 9-chloro-2-(cyclopropylmethyl)-6-phenyl-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen- 3-one |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a601036 |
Routes of administration | Oral |
ATC code | |
Legal status | |
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Pharmacokinetic data | |
Metabolism | Hepatic |
Elimination half-life | 36–200 hours |
Excretion | Renal |
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Prazepam is a
Indications
Prazepam is indicated for the short-term treatment of
Side effects
Side effects of prazepam are less profound than with other
Tolerance, dependence and withdrawal
Benzodiazepines can induce serious problems of addiction, which is one of the main reasons for their use being restricted to short-term use. A survey in Senegal found that the majority of doctors believed that their training in this area was generally poor. It was recommended that national authorities take urgent action regarding the rational use of benzodiazepines. Almost one-fifth of doctors ignored prescription guidelines regarding short-term use of benzodiazepines, and almost three-quarters of doctors regarded their training and knowledge of benzodiazepines to be inadequate. More training regarding benzodiazepines has been recommended for doctors.[19][20]
Contraindications and special caution
Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol or drug-dependent individuals and individuals with
Mechanism of action
Prazepam exerts its therapeutic effects primarily via modulating the
Pharmacokinetics
Prazepam is metabolised into descyclopropylmethylprazepam (also known as
Interactions
Prazepam may interact with
Overdose
The symptoms of an
Abuse potential
Prazepam like other benzodiazepines has abuse potential and can be
Toxicity
Animal studies have found prazepam taken during pregnancy results in delayed growth and causes reproductive abnormalities.[38][39][40]
Trade names
Common
See also
- Benzodiazepine
- Benzodiazepine dependence
- Long-term effects of benzodiazepines
References
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
- ^ US Patent 3192199 – Process for the production of I-CYCLO- ALKYL derivatives of I,X-BENZODIAZEPINE
- PMID 45081.
- PMID 2854609.
- PMID 858240.
- PMID 1959497.
- PMID 6106488.
- S2CID 7514074.
- S2CID 20150379.
- PMID 6389091.
- PMID 15107731.
- PMID 6148339.
- PMID 3330182.
- PMID 2080484.
- ^ PMID 6133535.
- PMID 6353434.
- PMID 6353268.
- PMID 7991010.
- S2CID 20619323.
- PMID 17582318.
- PMID 19900604.
- ^ PMID 6114911.
- PMID 8909973.
- PMID 8981061.
- S2CID 24492818.
- S2CID 25773207.
- PMID 4763144.
- PMID 15712230.
- PMID 1680631.
- S2CID 2179445.
- PMID 701422.
- PMID 6790396.
- S2CID 24414335. Archived from the originalon 2009-07-20.
- PMID 6116430.
- PMID 1816280.
- PMID 1354907.
- PMID 3797537.
- PMID 28555.
- PMID 4863.
- PMID 239442.
- ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2009-05-31.