Proerythroblast
 | This article needs additional citations for verification. (June 2020) |
| Proerythroblast | |
|---|---|
Normoblast | |
| Identifiers | |
| TH | H2.00.04.3.03002 |
| FMA | 83518 |
| Anatomical terms of microanatomy] | |
A proerythroblast (or rubriblast, or pronormoblast) is the earliest of four stages in
normoblast
.
In histology, it is very difficult to distinguish it from the other "-blast" cells (lymphoblast, myeloblast, monoblast, and megakaryoblast). The cytoplasm is blue in an H&E stain, indicating that it is basophilic.
Proerythroblasts arise from the
erythroblasts. In the mouse, proerythroblasts are large committed progenitors that express high levels of transferrin receptor (iron acquisition receptor), the erythropoietin receptor (EpoR), some c-Kit (stem cell factor receptor), and are Ter119 (cell surface molecule
)-positive. Their proliferative capacity is more limited compared to the preceding stage, the CFU-e.
GATA-1 dependent process that is augmented by the EpoR signaling) and decreasing in cell size, eventually removing their nuclei and being released into the bloodstream as a reticulocyte
. There are several Nucleoli on the nucleus and it occupies most of the cell volume. the chromatins are consist of a network of fine red pink strands. The distinguished feature of pro erythroblast to its corresponding myeloblast in granulocytic series is that it carries more basophilic peripheral cytoplasm.
"Pronormoblast" vs. "proerythroblast"
Some sources consider the terms "pronormoblast" and "proerythroblast" to be
synonyms.[citation needed] However, other sources[1]
consider "proerythroblast" to be a parent term, divided into the following two categories:
- "pronormoblast" - normal development
- "promegaloblast" - abnormal development
References
- Dorland's Medical Dictionary
External links
- Histology image: 01804loa – Histology Learning System at Boston University - "Bone Marrow and Hemopoiesis: bone marrow smear, erythroblast series with proerythroblast"
- Histology image: 75_11 at the University of Oklahoma Health Sciences Center
- Histology at KUMC blood-blood04
- Image and description at purdue.edu
- Histology of "promegaloblast" at marist.edu (pernicious anemia)
- Interactive image at usuarios.lycos.es
- Overview at temple.edu