Promegakaryocyte
A promegakaryocyte is a precursor cell for a megakaryocyte. It arises from a megakaryoblast, into a promegakaryocyte and then into a megakaryocyte, which will eventually break off and become a platelet.[1]
The developmental stages of the megakaryocyte are: CFU-Me (
When the megakaryoblast matures into the promegakaryocyte, it undergoes endoreduplication[2] and forms a promegakaryocyte which has multiple nuclei, azurophilic granules, and a basophilic cytoplasm.[3] The promegakaryocyte has rotary motion, but no forward migration.[4]
Promegakaryocytes and other precursor cells to megakaryocytes arise from pluripotential hematopoietic progenitors.[5] The megakaryoblast is then produced, followed by the promegakaryocyte, the granular megakaryocyte, and then the mature megakaryocyte.[6] When it is in its promegakaryocyte stage, it is considered an undifferentiated cell.[7]
Megakaryocyte pieces will eventually break off and begin circulating the body as platelets. Platelets are very important because of their role in blood clotting, immune response, and the formation of new blood vessels.[8]
References
- )
- ISBN 978-8131205921.
- ISBN 1841842338.
- ^ Hiraki K, Ofuji T, Kobayashi T, Sunami H, Awai K (January 31, 1956). "On the function of the Megakaryocyte (Motility, Separation of the Platelet and Phagocytosis), Observations Both in Idiopathic Thrombocytopenic Purpura and in Normal Adult". Acta Medicinae Okayama. 10 (2): 57–61. Retrieved July 21, 2017.
- OCLC 162572838.
- PMID 21250105, retrieved 2021-10-13
- PMID 32042021.
- PMID 26787735.
External links
- "Marrow aspirate, 10x. Promegakaryocyte" at ttuhsc.edu
- "Megakaryocytes: Promegakaryocyte" at bloodline.net
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