Propantheline bromide

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Propantheline bromide
Antimuscarinic
ATC code
)
Identifiers
  • N-isopropyl-N-methyl-N-{2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl}propan-2-aminium bromide
JSmol)
  • [Br-].O=C(OCC[N+](C(C)C)(C(C)C)C)C2c3c(Oc1c2cccc1)cccc3
  • InChI=1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1 checkY
  • Key:XLBIBBZXLMYSFF-UHFFFAOYSA-M checkY
 ☒NcheckY (what is this?)  (verify)

Propantheline bromide (

antimuscarinic agent used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome and similar conditions. This agent can also be used for patients who experience intense GI symptoms while tapering off of TCAs
. [1]

Indications

By relaxing the gut muscle, propantheline can relieve pain in conditions caused by

sweating because acetylcholine block also reduces secretions such as sweat and tears
.

Adverse effects

Side effects include tachycardia, constipation, hypersensitivity to light, dry mouth, and urinary retention. This can also be prescribed by dentists for certain patients who salivate excessively. By giving this medication it becomes easier to do "dry" dentistry.

Mechanism of action

Propantheline is one of a group of

muscarinic receptors present in various smooth muscular
tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.

References

  1. ISBN 0-8247-5426-3
    .
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