Proxymetacaine

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(Redirected from
Proparacaine
)
Proxymetacaine
Topical (eye drops)
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismPlasma
Identifiers
  • 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
JSmol)
  • O=C(OCCN(CC)CC)c1ccc(OCCC)c(c1)N
  • InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3 checkY
  • Key:KCLANYCVBBTKTO-UHFFFAOYSA-N checkY
  (verify)

Proxymetacaine (

INN) or proparacaine (USAN) is a topical anesthetic drug of the aminoester
group.

Clinical pharmacology

Proxymetacaine is a local anesthetic which on topical application penetrates sensory nerve endings in the corneal tissue.[2]

Mechanism of action

Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.[3]

Indications and usage

Proxymetacaine hydrochloride ophthalmic solution (

tonometry, gonioscopy, removal of foreign bodies, or other similar procedures requiring topical anesthesia of the cornea and conjunctiva.[4]

Warnings

Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. Prolonged use of this or any other topical ocular anesthetic may produce permanent

visual loss
.

How supplied

Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. Although it is no longer on patent, it is still marketed under the trade names Alcaine, Ak-Taine, and others. Proparacaine 0.5% is marketed as Poencaina by Poen Laboratories.[5]

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. PMID 6472792
    .
  3. .
  4. .
  5. ^ "Poen-Caina generic. Price of poen-caina. Uses, Indications and Description". ndrugs. Retrieved 15 March 2018.