Propylene glycol

Source: Wikipedia, the free encyclopedia.
Not to be confused with Polypropylene glycol, Ethylene glycol, or Polyethylene glycol.
This article is about 1,2-propanediol. For other propylene glycols, see Propanediol.
Propylene glycol[1]
Propylene glycol
ball-and-stick model
ball-and-stick model
Space-filling model
Space-filling model
Names
Preferred IUPAC name
Propane-1,2-diol
Other names
  • Propylene glycol
  • α-Propylene glycol
  • 1,2-Propanediol
  • 1,2-Dihydroxypropane
  • Methyl ethyl glycol
  • Methylethylene glycol
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
 100.000.307 Edit this at Wikidata
EC Number
  • 200-338-0
E number E1520 (additional chemicals)
KEGG
RTECS number
  • TY6300000
UNII
  • InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3 checkY
    Key: DNIAPMSPPWPWGF-UHFFFAOYSA-N checkY
  • CC(O)CO
Properties
C3H8O2
Molar mass 76.095 g·mol−1
Appearance colourless liquid
Odor odorless
Density 1.036 g/cm3
Melting point −59 °C (−74 °F; 214 K)
Boiling point 188.2 °C (370.8 °F; 461.3 K)
Miscible
Solubility in ethanol Miscible
Solubility in diethyl ether Miscible
Solubility in acetone Miscible
Solubility in chloroform Miscible
log P -1.34[2]
Thermal conductivity
 0.34 W/m-K (50% H2O @ 90 °C (194 °F))
Viscosity 0.042 Pa·s
Pharmacology
QA16QA01 (WHO)
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g. sodium chlorideFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
0
1
0
Related compounds
Related
glycols
1,3-propanediol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Propylene glycol (

IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. Its chemical formula
is CH3CH(OH)CH2OH. As it contains two
miscible with a broad range of solvents, including water, acetone, and chloroform. In general, glycols[5] are non-irritating and have very low volatility.[6]

It is produced on a large scale primarily for the production of

E-number E1520 for food applications. For cosmetics and pharmacology, the number is E490. Propylene glycol is also present in propylene glycol alginate, which is known as E405. Propylene glycol is a compound which is GRAS (generally recognized as safe) by the US Food and Drug Administration
under 21 CFR x184.1666, and is also approved by the FDA for certain uses as an indirect food additive. Propylene glycol is approved and used as a vehicle for topical, oral, and some intravenous pharmaceutical preparations in the U.S. and in Europe.

Structure

The compound is sometimes called (alpha) α-propylene glycol to distinguish it from the

racemate
. The S-isomer is produced by biotechnological routes.

Production

Industrial

Industrially, propylene glycol is mainly produced from propylene oxide (for food-grade use). According to a 2018 source, 2.16 M tonnes are produced annually.[6] Manufacturers use either non-catalytic high-temperature process at 200 °C (392 °F) to 220 °C (428 °F), or a catalytic method, which proceeds at 150 °C (302 °F) to 180 °C (356 °F) in the presence of ion exchange resin or a small amount of sulfuric acid or alkali.[7]

Final products contain 20% propylene glycol, 1.5% of dipropylene glycol, and small amounts of other polypropylene glycols.[8] Further purification produces finished industrial grade or USP/JP/EP/BP grade propylene glycol that is typically 99.5% or greater. Use of USP (US Pharmacopoeia) propylene glycol can reduce the risk of Abbreviated New Drug Application (ANDA) rejection.[9]

Propylene glycol can also be obtained from glycerol, a byproduct from the production of biodiesel.[6] This starting material is usually reserved for industrial use because of the noticeable odor and taste that accompanies the final product.

Laboratory

(S)-Propanediol is synthesized via fermentation methods.

deoxysugars are also precursor to the 1,2-diol.[6]

A small-scale, nonbiological route from D-mannitol is illustrated in the following scheme:[10]

Applications

Polymers

Forty-five percent of propylene glycol produced is used as a chemical feedstock for the production of unsaturated

thermoset plastics. Related to this application, propylene glycol reacts with propylene oxide to give oligomers and polymers that are used to produce polyurethanes.[6]
Propylene glycol is used in water-based acrylic architectural paints to extend dry time which it accomplishes by preventing the surface from drying due to its slower evaporation rate compared to water.

Food and drug

Propylene glycol is also used in various edible items such as coffee-based drinks,

insoluble in water utilize propylene glycol as a solvent and carrier; benzodiazepine tablets are one example.[14] Propylene glycol is also used as a solvent and carrier for many pharmaceutical capsule preparations. Additionally, certain formulations of artificial tears use propylene glycol as an ingredient.[15]

de-ice
aircraft

Antifreeze

The

eutectic composition/temperature is 60:40 propylene glycol:water/−60 °C.[18][19] The −50 °F/−45 °C commercial product is, however, water rich; a typical formulation is 40:60.[20]

Electronic cigarettes liquid

A bottle of flavored e-liquid for vaping shows propylene glycol as one of the main ingredients along with vegetable glycerin.

Propylene glycol, vegetable

flavorants.[22]

Miscellaneous applications

Safety in humans

When used in average quantities, propylene glycol has no measurable effect on development and/or reproduction on animals and probably does not adversely affect human development or reproduction without active use.

Vitamin E acetate has also been identified in this controversy.[33]

Oral administration

The acute oral toxicity of propylene glycol is very low, and large quantities are required to cause perceptible health effects in humans; in fact, the toxicity of propylene glycol is one third of ethanol's.[34] Propylene glycol is metabolized in the human body into pyruvic acid (a normal part of the glucose-metabolism process, readily converted to energy), acetic acid (handled by ethanol-metabolism), lactic acid (a normal acid generally abundant during digestion),[35] and propionaldehyde (a potentially hazardous substance).[36][37][38] According to the Dow Chemical Company, the LD50 (dose that kills 50% of the test population) for rats is 20 g/kg (oral/rat).[39][40]

Toxicity generally occurs at plasma concentrations over 4 g/L, which requires extremely high intake over a relatively short period of time, or when used as a vehicle for drugs or vitamins given intravenously or orally in large

bolus doses.[41] It would be nearly impossible to reach toxic levels by consuming foods or supplements, which contain at most 1 g/kg of PG, except for alcoholic beverages in the US which are allowed 5 percent = 50 g/kg.[42] Cases of propylene glycol poisoning are usually related to either inappropriate intravenous administration or accidental ingestion of large quantities by children.[43]

The potential for long-term oral toxicity is also low. In a National Toxicology Program continuous breeding study, no effects on fertility were observed in male or female mice that received propylene glycol in drinking water at doses up to 10100 mg/kg bw/day. No effects on fertility were seen in either the first or second generation of treated mice.[29] In a 2-year study, 12 rats were provided with feed containing as much as 5% propylene glycol, and showed no apparent ill effects.[44] Because of its low chronic oral toxicity, propylene glycol was classified by the U. S. Food and Drug Administration as "generally recognized as safe" (GRAS) for use as a direct food additive, including frozen foods such as ice cream and frozen desserts.[42][45] The GRAS designation is specific to its use in food, and does not apply to other uses.[46]

Skin and eye contact

electronic cigarettes
.

Propylene glycol may be non-irritating to the skin, see section Allergic reaction below for details on allergic reactions.[47] Undiluted propylene glycol is minimally irritating to the eye, producing slight transient conjunctivitis; the eye recovers after the exposure is removed.

A 2018 human volunteer study found that 10 male and female subjects undergoing 4 hours exposures to concentrations of up to 442 mg/m3 and 30 minutes exposures to concentrations of up to 871 mg/m3 in combination with moderate exercise did not show pulmonary function deficits, or signs of ocular irritation, with only slight symptoms of respiratory irritation reported.[48]

Propylene glycol has not caused sensitization or carcinogenicity in laboratory animal studies, nor has it demonstrated genotoxic potential.[49][50]

Inhalation

Inhalation of propylene glycol vapors appears to present no significant hazard in ordinary applications.

e-cigarette liquids, the use of which presents a novel form of exposure. The potential hazards of chronic inhalation of propylene glycol or the latter substance as a whole are as-yet unknown.[53]

According to a 2010 study, the concentrations of PGEs (counted as the sum of propylene glycol and

eczema, and allergies, with increased risk ranging from 50% to 180%. This concentration has been linked to use of water-based paints and water-based system cleansers. However, the study authors write that glycol ethers and not propylene glycol are the likely culprit.[54][55][56]

Intravenous administration

Studies with intravenously administered propylene glycol have resulted in LD50 values in rats and rabbits of 7 mL/kg BW.

nitroglycerin to an elderly man may have induced coma and acidosis.[61]
However, no confirmed lethality from propylene glycol was reported.

Animals

Propylene glycol is an approved food additive for dog and sugar glider food under the category of animal feed and is generally recognized as safe for dogs,[62] with an LD50 of 9 mL/kg. The LD50 is higher for most laboratory animals (20 mL/kg).[63] However, it is prohibited for use in food for cats due to links to Heinz body formation and a reduced lifespan of red blood cells.[64] Heinz body formation from MPG has not been observed in dogs, cattle, or humans.

PG has been used in the

acetaminophen, while increasing conversion of ruminal PG to propionate, and aid[s] in the closure of energy deficit in cattle."[65]

Allergic reaction

Estimates on the prevalence of propylene glycol allergy range from 0.8% (10% propylene glycol in aqueous solution) to 3.5% (30% propylene glycol in aqueous solution).[66][67][68] The North American Contact Dermatitis Group (NACDG) data from 1996 to 2006 showed that the most common site for propylene glycol contact dermatitis was the face (25.9%), followed by a generalized or scattered pattern (23.7%).[66] Investigators believe that the incidence of allergic contact dermatitis to propylene glycol may be greater than 2% in patients with eczema or fungal infections, which are very common in countries with lesser sun exposure and lower-than-normal vitamin D balances. Therefore, propylene glycol allergy is more common in those countries.[69]

Because of its potential for allergic reactions and frequent use across a variety of topical and systemic products, propylene glycol was named the American Contact Dermatitis Society's Allergen of the Year for 2018.[70][71] Recent publication from The Mayo Clinic reported 0.85% incidence of positive patch tests to propylene glycol (100/11,738 patients) with an overall irritant rate of 0.35% (41/11,738 patients) during a 20-year period of 1997–2016.[72] 87% of the reactions were classified as weak and 9% as strong. The positive reaction rates were 0%, 0.26%, and 1.86% for 5%, 10%, and 20% propylene glycol respectively, increasing with each concentration increase. The irritant reaction rates were 0.95%, 0.24%, and 0.5% for 5%, 10%, and 20% propylene glycol, respectively. Propylene glycol skin sensitization occurred in patients sensitive to a number of other concomitant positive allergens, most common of which were: Myroxylon pereirae resin, benzalkonium chloride, carba mix, potassium dichromate, neomycin sulfate; for positive propylene glycol reactions, the overall median of 5 and mean of 5.6 concomitant positive allergens was reported.

Environmental impacts

Propylene glycol occurs naturally, probably as the result of anaerobic catabolism of sugars in the human gut. It is degraded by vitamin B12-dependent enzymes, which convert it to propionaldehyde.[73]

Propylene glycol is expected to degrade rapidly in water from biological processes, but is not expected to be significantly influenced by hydrolysis, oxidation,

volatilization, bioconcentration, or adsorption to sediment.[74]
Propylene glycol is readily biodegradable under aerobic conditions in freshwater, in seawater and in soil. Therefore, propylene glycol is considered as not persistent in the environment.

Propylene glycol exhibits a low degree of toxicity toward aquatic organisms. Several guideline studies available for freshwater fish with the lowest observed lethal concentration of 96-h

Scophthalmus maximus
.

Although propylene glycol has low toxicity, it exerts high levels of

dissolved oxygen (DO) in the water column are consumed when microbial populations decompose propylene glycol.[75]
: 2–23 

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External links

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