Prostaglandin D2 synthase
| PTGDS | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 9: 136.98 – 136.98 Mb | Chr 2: 25.36 – 25.36 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme that in humans is encoded by the PTGDS gene.[5][6]
Function
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of
androgenetic alopecia).[7]
Clinical use
Prostaglandin D2 synthase is used clinically as a diagnostic marker for
head trauma
severity. In a medical context, the older term "beta-trace protein" is frequently used to refer to PTGDS.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000107317 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015090 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1902577.
- ^ a b "Entrez Gene: PTGDS prostaglandin D2 synthase 21kDa (brain)".
- PMID 22440736.
- PMID 11841726.
Further reading
- White DM, Mikol DD, Espinosa R, Weimer B, Le Beau MM, Stefansson K (Nov 1992). "Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase". The Journal of Biological Chemistry. 267 (32): 23202–8. PMID 1385416.
- Kuruvilla AP, Hochwald GM, Ghiso J, Castaño EM, Pizzolato M, Frangione B (Nov 1991). "Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid". Brain Research. 565 (2): 337–40. S2CID 54405256.
- Zahn M, Mäder M, Schmidt B, Bollensen E, Felgenhauer K (May 1993). "Purification and N-terminal sequence of beta-trace, a protein abundant in human cerebrospinal fluid". Neuroscience Letters. 154 (1–2): 93–5. S2CID 42018337.
- Harrington MG, Aebersold R, Martin BM, Merril CR, Hood L (1993). "Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein". Applied and Theoretical Electrophoresis. 3 (5): 229–34. PMID 7692978.
- Bastien L, Sawyer N, Grygorczyk R, Metters KM, Adam M (Apr 1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype". The Journal of Biological Chemistry. 269 (16): 11873–7. PMID 8163486.
- Funk CD, Furci L, FitzGerald GA, Grygorczyk R, Rochette C, Bayne MA, Abramovitz M, Adam M, Metters KM (Dec 1993). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype". The Journal of Biological Chemistry. 268 (35): 26767–72. PMID 8253813.
- Abramovitz M, Boie Y, Nguyen T, Rushmore TH, Bayne MA, Metters KM, Slipetz DM, Grygorczyk R (Jan 1994). "Cloning and expression of a cDNA for the human prostanoid FP receptor". The Journal of Biological Chemistry. 269 (4): 2632–6. PMID 8300593.
- Hoffmann A, Conradt HS, Gross G, Nimtz M, Lottspeich F, Wurster U (Aug 1993). "Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase". Journal of Neurochemistry. 61 (2): 451–6. S2CID 34300607.
- Leone MG, Saso L, Del Vecchio A, Mo MY, Silvestrini B, Cheng CY (Aug 1993). "Micropurification of two human cerebrospinal fluid proteins by high performance electrophoresis chromatography". Journal of Neurochemistry. 61 (2): 533–40. S2CID 29843974.
- Giacomelli S, Leone MG, Grima J, Silvestrini B, Cheng CY (Feb 1996). "Astrocytes synthesize and secrete prostaglandin D synthetase in vitro". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1310 (3): 269–76. PMID 8599604.
- Blödorn B, Mäder M, Urade Y, Hayaishi O, Felgenhauer K, Brück W (May 1996). "Choroid plexus: the major site of mRNA expression for the beta-trace protein (prostaglandin D synthase) in human brain". Neuroscience Letters. 209 (2): 117–20. S2CID 34159760.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548.
- Yamashima T, Sakuda K, Tohma Y, Yamashita J, Oda H, Irikura D, Eguchi N, Beuckmann CT, Kanaoka Y, Urade Y, Hayaishi O (Apr 1997). "Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process". The Journal of Neuroscience. 17 (7): 2376–82. PMID 9065498.
- White DM, Takeda T, DeGroot LJ, Stefansson K, Arnason BG (May 1997). "Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element". The Journal of Biological Chemistry. 272 (22): 14387–93. PMID 9162076.
- Eguchi Y, Eguchi N, Oda H, Seiki K, Kijima Y, Matsu-ura Y, Urade Y, Hayaishi O (Dec 1997). "Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14689–94. PMID 9405674.
- Tokugawa Y, Kunishige I, Kubota Y, Shimoya K, Nobunaga T, Kimura T, Saji F, Murata Y, Eguchi N, Oda H, Urade Y, Hayaishi O (Feb 1998). "Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma". Biology of Reproduction. 58 (2): 600–7. PMID 9475419.
- Saso L, Leone MG, Sorrentino C, Giacomelli S, Silvestrini B, Grima J, Li JC, Samy E, Mruk D, Cheng CY (Nov 1998). "Quantification of prostaglandin D synthetase in cerebrospinal fluid: a potential marker for brain tumor". Biochemistry and Molecular Biology International. 46 (4): 643–56. S2CID 29770550.
- Blödorn B, Brück W, Tumani H, Michel U, Rieckmann P, Althans N, Mäder M (Sep 1999). "Expression of the beta-trace protein in human pachymeninx as revealed by in situ hybridization and immunocytochemistry". Journal of Neuroscience Research. 57 (5): 730–4. S2CID 23555031.
- Pinzar E, Kanaoka Y, Inui T, Eguchi N, Urade Y, Hayaishi O (Apr 2000). "Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep". Proceedings of the National Academy of Sciences of the United States of America. 97 (9): 4903–7. PMID 10781097.