Protamine sulfate
Clinical data | ||
---|---|---|
Trade names | Prosulf, others | |
AHFS/Drugs.com | Monograph | |
Routes of administration | IV | |
Legal status | ||
Legal status | ||
ECHA InfoCard | 100.113.361 |
Protamine sulfate is a medication that is used to reverse the effects of
Common side effects include
Protamine sulfate was approved for medical use in the United States in 1969.
Medical uses
Protamine sulfate is usually administered to reverse the large dose of heparin administered during certain surgeries, especially heart surgery where anti-coagulation is necessary to prevent clot formation within the cardiopulmonary bypass pump apparatus. A dose of protamine is given, by drip administered over several minutes, once the patient is off-pump, when extracorporeal circulation and anticoagulation are no longer needed.
It is also used in gene transfer, protein purification and in tissue cultures as a
Protamine is used in
Dosage
Dosage for heparin reversal is 0.5mg to 1.0 mg mg protamine sulfate IV for every 100 IU of active heparin. Partial thromboplastin time (PTT) should be monitored at 5 to 15 minutes after dose then in 2–8 hours afterward.
Adverse effects
Avoiding rapid
Mechanism
It is a highly
History
Protamine sulfate replaced hexadimethrine bromide (Polybrene), another cationic agent that was the original heparin reversal agent in the early days of heart surgery, until studies in the 1960s suggested that hexadimethrine bromide might cause kidney failure when used in doses in excess of its therapeutic range.[15]
References
- FDA. Retrieved 22 Oct 2023.
- ^ a b "Prosulf 10mg/ml Solution for Injection - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Archived from the original on 20 December 2016. Retrieved 14 December 2016.
- ^ a b c d e f g h "Protamine Sulfate". The American Society of Health-System Pharmacists. Archived from the original on 6 November 2016. Retrieved 8 December 2016.
- ^ "Protamine sulfate". www.drugbank.ca. Retrieved 14 February 2019.
- ISBN 9789241547659.
- ^ "Protamine Use During Pregnancy". Drugs.com. Archived from the original on 21 December 2016. Retrieved 14 December 2016.
- hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ISBN 9781455740420.
- S2CID 22101764.
- PMID 2786000.
- PMID 6743419.
- ^ PMID 6334459.
- S2CID 42687628.
- S2CID 22038832.
- PMID 14281435.
External links
- Protamine+Sulfate at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- "Protamine Sulfate". Drug Information Portal. U.S. National Library of Medicine.