Protein subfamily

Source: Wikipedia, the free encyclopedia.

Protein subfamily is a level of protein classification, based on their close evolutionary relationship. It is below the larger levels of protein superfamily and protein family.[1]

Proteins typically share greater sequence and function similarities with other subfamily members than they do with members of their wider family.

interaction partners.[3] These are stricter criteria than for a family, where members have similar structures, but may be more distantly related and so have different interfaces. Subfamilies are assigned by a variety of methods, including sequence similarity,[4] motifs linked to function,[5] or phylogenetic clade.[6][7]
There is no exact and consistent distinction between a subfamily and a family. The same group of proteins may sometimes be described as a family or a subfamily, depending on the context.

References

  1. ^ a b "What are protein families?". EMBL-EBI Train online. 2011-11-18. Retrieved 2018-03-08.
  2. PMID 26434392
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  3. PMID 20133844
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  4. PMID 17708678
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  5. PMID 7651832
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  6. PMID 11470834
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  7. PMID 26578592
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External links


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