Pure red cell aplasia
| Pure red cell aplasia | |
|---|---|
leukocyte. Pure red cell aplasia affects the red blood cells in particular. | |
| Specialty | Hematology  |
Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of
white blood cells. In PRCA, the bone marrow ceases to produce red blood cells. There are multiple etiologies that can cause PRCA. The condition has been first described by Paul Kaznelson in 1922.[1]
Signs and symptoms
Signs and symptoms may include:
- Pale appearance
- Rapid heart rate
- Fatigue
Causes
Causes of PRCA include:
- Autoimmune disease.
- Thymoma.[2]
- Viral infections such as HIV, herpes, parvovirus B19 (Fifth disease),[3] or hepatitis.[citation needed]
- T-cell large granular lymphocyte leukemia is well recognized, especially in China.[4]
- Idiopathic. Many cases of PRCA are considered idiopathic in that there is no discernible cause detected.[5]
- Drugs such as mycophenolic acid[6] or erythropoietin.[7][citation needed]
- Congenital. The term "hereditary pure red cell aplasia" has been used to refer to Diamond–Blackfan anemia.[8]
Diagnosis
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Treatment
PRCA is considered an
It has also been shown to respond to treatments with rituximab and tacrolimus.[citation needed]
For cases related to B19 parvovirus, administration of commercial immunoglobulin can treat or cure parvovirus by replacing neutralizing antibodies.[11]
See also
- Diamond–Blackfan anemia (genetic red cell aplasia)
- Aplastic anemia (aplasia affecting other bone marrow cells as well)
References
- ^ Kaznelson P (1922). "Zur Entstehung der Blutplättchen". Verh Dtsch Ges Inn Med. 34: 557–8.
- PMID 18166782.
- S2CID 39011566.
- PMID 9930071.
- PMID 18576941.
- ^ Petrochko C (2009). "FDA Strengthens Warning on Transplant Drug." Medpage Today. 14 August 2009. Accessed 19 August 2009.
- S2CID 24613046.
- ^ Online Mendelian Inheritance in Man (OMIM): 105650
- PMID 17640861.
- PMID 18510682.
- ^ National Organization for Rare Disorders. (2003). Nord Guide to Rare Disorders. Lippincott Williams & Wilkins.