Purine analogue
(Redirected from
Purine analogues
)Purine analogues are antimetabolites that mimic the structure of metabolic purines.
Examples
- Nucleobase analogues
- Thiopurines such as thioguanine are used to treat acute leukemias and remissions in acute granulocytic leukemias.
- cell immunity and humoral immunity. It also successfully suppresses autoimmunity.
- Mercaptopurine
- Thioguanine
- Thiopurines such as thioguanine are used to treat acute leukemias and remissions in acute granulocytic leukemias.
- Nucleoside analogues
- Clofarabine
- Pentostatin and cladribine are adenosine analogs that are used primarily to treat hairy cell leukemia.
- Nucleotide analogues
- DNA ligase I, and is S phase-specific (since these enzymes are highly active during DNA replication).
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Thioguanine -
Medical uses
Purine antimetabolites are commonly used to treat cancer by interfering with DNA replication.[1]
References
- PMID 19476376.
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