Pyrimidine analogue
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Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.
Examples
- Nucleobase analogues
- Fluorouracil (5FU), which inhibits thymidylate synthase
- Floxuridine (FUDR)
- 6-azauracil (6-AU)
- Nucleoside analogues
- Cytarabine (Cytosine arabinoside)
- Gemcitabine
- Nucleotide analogues
Medical uses
Pyrimidine antimetabolites are commonly used to treat cancer by interfering with DNA replication.[1]
References
- PMID 19476376.
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CNTs
Tooltip Concentrative nucleoside transportersENTs
Tooltip Equilibrative nucleoside transporters(inhibitors)
| XOTooltip Xanthine oxidase | |
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| Others |
See also: Receptor/signaling modulators
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