Pyritinol

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Pyritinol
Clinical data
ATC code
Pharmacokinetic data
Elimination half-life2.5 hours
Identifiers
  • 5,5'-[dithiobis(methylene)]bis[4-(hydroxymethyl)-2-methylpyridin-3-ol]
JSmol)
  • Oc1c(c(cnc1C)CSSCc2c(c(O)c(nc2)C)CO)CO
  • InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3 checkY
  • Key:SIXLXDIJGIWWFU-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pyritinol also called pyridoxine disulfide or pyrithioxine (European drug names Encephabol, Encefabol, Cerbon 6) is a semi-synthetic water-soluble analog of vitamin B6 (Pyridoxine HCl). It was produced in 1961 by Merck Laboratories by bonding 2 vitamin B6 compounds (pyridoxine) together with a disulfide bridge. Since the 1970s, it has been a prescription and OTC drug in several countries for cognitive disorders, rheumatoid arthritis,[1] and learning disorders in children. Since the early 1990s it has been sold as a nootropic dietary supplement in the United States.

Availability

It is approved for "symptomatic treatment of chronically impaired brain function in dementia syndromes" and for "supportive treatment of sequelae of craniocerebral trauma" in various European countries, including Austria, Germany, France, Italy, Portugal, and Greece. In France it is also approved for

disease modifying drug, on the basis of the results of clinical trials. In many countries it is available over the counter and is widely advertised on the internet as being for "memory disturbances."[citation needed
]

Effects

review refs needed

Adverse effects

Adverse effects include nausea, headache,

cholestatic hepatitis when on several drugs for certain diseases.[4]

Other rare side effects: acute pancreatitis[5] and photoallergic eruption.[6]

See also

References

  1. PMID 8495257
    .
  2. PMID 8324277
    .
  3. ISBN 978-0-444-89775-6
    .
  4. PMID 15001508
    .
  5. PMID 9679051
    .
  6. S2CID 28810619
    .

External links

  • Media related to Pyritinol at Wikimedia Commons
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