Pyrophosphoric acid

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Pyrophosphoric acid
Chemical structure of pyrophosphoric acid
3D model of pyrophosphoric acid
Names
IUPAC names
Diphosphoric acid
μ-oxido-bis(dihydroxidooxidophosphorus)
Other names
Pyrophosphoric acid
Phosphonophosphoric acid
Phosphono dihydrogenphosphate
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
 100.017.795 Edit this at Wikidata
IUPHAR/BPS
UNII
  • InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6) checkY
    Key: XPPKVPWEQAFLFU-UHFFFAOYSA-N checkY
  • InChI=1/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)
    Key: XPPKVPWEQAFLFU-UHFFFAOYAX
  • O=P(O)(O)OP(=O)(O)O
Properties
H4P2O7
Molar mass 177.97 g/mol
Melting point 71.5 °C (160.7 °F; 344.6 K)
Extremely soluble
Solubility Very soluble in alcohol, ether
Conjugate base
 Pyrophosphate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pyrophosphoric acid, also known as diphosphoric acid, is the inorganic compound with the formula H4P2O7 or, more descriptively, [(HO)2P(O)]2O. Colorless and odorless, it is soluble in

Anions, salts, and esters of pyrophosphoric acid are called pyrophosphates
.

Preparation

It can be prepared by reaction of phosphoric acid with phosphoryl chloride:[2]

5 H3PO4 + POCl3 → 3 H4P2O7 + 3 HCl

It can also be prepared by ion exchange from sodium pyrophosphate or by treating lead pyrophosphate with hydrogen sulfide.[1]

Boiling the water from

polyphosphoric acids are produced, the maximum pyrophosphoric acid concentration remains below 50% and occurs slightly before what would otherwise be pure pyrophosphoric acid.[3]

Reactions

Pyrophosphoric acid is a tetraprotic acid, with four distinct pKa's:[4]

H4P2O7 ⇌ [H3P2O7]− + H+, pKa = 0.85
[H3P2O7]− ⇌ [H2P2O7]2− + H+, pKa = 1.96
[H2P2O7]2− ⇌ [HP2O7]3− + H+, pKa = 6.60
[HP2O7]3− ⇌ [P2O7]4− + H+, pKa = 9.41

The pKa's occur in two distinct ranges because deprotonations occur on separate phosphate groups. For comparison with the pKa's for phosphoric acid are 2.14, 7.20, and 12.37.

At physiological pH's, pyrophosphate exists as a mixture of doubly and singly protonated forms.

When molten, pyrophosphoric acid rapidly converts to an equilibrium mixture of phosphoric acid, pyrophosphoric acid and polyphosphoric acids. The percentage by weight of pyrophosphoric acid is around 40% and it is difficult to recrystallise from the melt.

Even in cold water, pyrophosphoric acid hydrolyses to phosphoric acid. All polyphosphoric acids behave similarly.[5]

H4P2O7 + H2O → 2 H3PO4

Safety

While pyrophosphoric acid is corrosive, it is not known to be otherwise toxic.[6]

History

The name pyrophosphoric acid was given by a "Mr. Clarke of Glasgow" in 1827 who is credited with its discovery following the heating to red heat of a

sodium phosphate salt. It was found that phosphoric acid when heated to red heat formed pyrophosphoric acid that was readily converted to phosphoric acid by hot water.[7]

See also

References

  1. ^
    S2CID 246266565
    .
  2. ^ R. Klement (1963). "Condensed Orthophosphates". In G. Brauer (ed.). Handbook of Preparative Inorganic Chemistry, 2nd Ed. Vol. 2. NY, NY: Academic Press. p. 546.
  3. ISBN 978-3-319-17081-7
    , retrieved 2023-02-11
  4. PMID 34603734
    .
  5. ISBN 0-444-89307-5
    .
  6. ^ Material Safety Data Sheet: Pyrophosphoric acid MSDS www.sciencelab.com
  7. ^ Beck, Lewis Caleb (1834). A Manual of Chemistry: Containing a Condensed View of the Present State of the Science, with Copious References to More Extensive Treatises, Original Papers, Etc. E.W & C Skinner. p. 160. Retrieved January 30, 2015.

External links

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