Quinapril
Clinical data | |
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Trade names | Accupril, others |
Other names | Quinapril hydrochloride (USAN US) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692026 |
License data | |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 97% |
Elimination half-life | 2 hours |
Identifiers | |
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JSmol) | |
Melting point | 120 to 130 °C (248 to 266 °F) |
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Quinapril, sold under the brand name Accupril
Common side effects include headaches, dizziness, feeling tired, and cough.
Quinapril was patented in 1980 and came into medical use in 1989.
Medical uses
Quinapril is
Contraindications
Contraindications include:[9]
- Pregnancy
- Impaired renal and liver function
- Patients with a history of angioedema related to previous treatment with an ACE inhibitor
- Hypersensitivity to Quinapril
Side effects
Mechanism of action
Quinapril inhibits
Partial Recall
In April of 2022, Pfizer voluntarily recalled five batches of the drug because of the presence of a nitrosamine, NNitroso-quinapril. Testing found that the amount of nitrosamines was above the acceptable daily intake level (all humans are exposed to nitrosamines up to a certain daily level by cured and grilled meats, water, dairy products, and vegetables) set by the U.S.'s Food and Drug Administration (FDA). Though long-term ingestion of NNitroso-quinapril potentially might cause cancer in some individuals, there is not believed to be an imminent risk of harm.[11][12]
References
- ^ a b c d e "Accupril- quinapril hydrochloride tablet, film coated Accupril- quinapril tablet, film coated". DailyMed. 26 August 2021. Retrieved 25 March 2022.
- ^ "ACCUPRIL® Indications and Usage (quinapril HCl) | Pfizer Medical Information - US". www.pfizermedicalinformation.com. Retrieved 25 October 2023.
- ^ a b c d e f "Quinapril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
- ^ "Quinapril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
- ISBN 9783527607495.
- ISBN 9780857113382.
- ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
- ^ "Quinapril - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
- ^ "Angiotensin-Converting Enzyme (ACE) Inhibitors". Cleveland Clinic. Retrieved 25 October 2023.
- ^ "Angiotensin-Converting Enzyme (ACE) Inhibitors". Cleveland Clinic. Retrieved 25 October 2023.
- ^ "Pfizer recalls blood pressure tablets due to increased cancer risk". MSN.
- ^ "Pfizer Voluntary Nationwide Recall of Lots of ACCUPRIL® (Quinapril HCL) Due to N-Nitroso-Quinapril Content". Food and Drug Administration. 22 April 2022.
External links
- "Quinapril hydrochloride". Drug Information Portal. U.S. National Library of Medicine.