RaTG13
BatCoV RaTG13 | |
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Virus classification | |
(unranked): | Virus |
Realm: | Riboviria |
Kingdom: | Orthornavirae |
Phylum: | Pisuviricota |
Class: | Pisoniviricetes |
Order: | Nidovirales |
Family: | Coronaviridae |
Genus: | Betacoronavirus |
Subgenus: | Sarbecovirus |
Species: | Severe acute respiratory syndrome–related coronavirus |
Strain: | BatCoV RaTG13
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Synonyms[1] | |
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Bat coronavirus RaTG13 is a SARS-like
History
In spring 2012, three miners cleaning bat feces in an abandoned copper mine near the town of Tongguan in Mojiang Hani Autonomous County developed fatal pneumonia.[11] Out of concerns that the miner's cases could represent a novel disease,[12] serum samples collected from the miners were sent to the Wuhan Institute of Virology and tested by Shi Zhengli and her group for Ebola virus, Nipah virus, and bat SARSr-CoV Rp3. The samples tested negative.[3][13][11]
In order to uncover a possible cause of the infection, different animals (including bats, rats, and
In 2020, Shi and her group retested the serum samples from the miners for SARS-CoV-2. The samples tested negative.[3]
In 2020, the strain identified in the sample was renamed from the original Ra4991 (4991st sample collected from Rhinolophus affinis) to "RaTG13", to reflect the originating bat species (Ra from Rhinolophus affinis), geographic location (TG from Tongguan), and year collected (13 from 2013).[14] The name change has been considered innuendo by advocates of the lab leak theory for the COVID-19 pandemic.[14]
Virology
The sequence of RaTG13 was reconstructed from
Based on its sequence, RaTG13 is a
RaTG13 bears strong resemblance to the
The binding affinity between RATG13 and hACE2 is lower than that between SARS-CoV-2 RBD and hACE2.[19]
Phylogenetics
Phylogenetic tree
A phylogenetic tree based on whole-genome sequences of SARS-CoV-2 and related coronaviruses is:[20][21]
SARS‑CoV‑2 related coronavirus | |
SARS-CoV-1 , 79% to SARS-CoV-2
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See also
References
- ^ "Taxonomy browser (Bat coronavirus RaTG13)". www.ncbi.nlm.nih.gov. Retrieved 2021-01-02.
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- ^ "Newly Discovered Bat Viruses Give Hints to Covid's Origins". New York Times. 2021-10-14.
- ^ PMID 24865545.
- ^ a b "The 'Occam's Razor Argument' Has Not Shifted in Favor of a Lab Leak". Snopes.com. Snopes. 16 July 2021. Retrieved 18 July 2021.
- ^ PMID 26920708.
- ^ a b "The 'Occam's Razor Argument' Has Not Shifted in Favor of a COVID Lab Leak". Snopes.com. Snopes. 16 July 2021.
- S2CID 245703661.
- ^ PMID 34626592.
- NCBI. Retrieved 2020-03-28.
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- ^ PMID 34753934.
- PMID 32416074.
- PMID 32015507.
- S2CID 246902858.