Ravn virus
| Ravn virus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota
|
| Class: | Monjiviricetes |
| Order: | Mononegavirales |
| Family: | Filoviridae |
| Genus: | Marburgvirus |
| Species: | Marburg marburgvirus |
| Virus: | Ravn virus
|
Ravn virus (/ˈrævən/;[1] RAVV) is a close relative of Marburg virus (MARV). RAVV causes Marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever.[2] RAVV is a Select agent,[3] World Health Organization Risk Group 4 Pathogen (requiring Biosafety Level 4-equivalent containment),[4] National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogen,[5] Centers for Disease Control and Prevention Category A Bioterrorism Agent,[6] and listed as a Biological Agent for Export Control by the Australia Group.[7]
Use of term
Ravn virus (today abbreviated RAVV, but then considered identical to Marburg virus) was first described in 1987 and is named after a 15-year old Danish boy who fell ill and died from it.
Previous designations
Ravn virus was first introduced as a new subtype of Marburg virus in 1996.[8] In 2006, a whole-genome analysis of all marburgviruses revealed the existence of five distinct genetic lineages. The genomes of representative isolates of four of those lineages differed from each other by only 0-7.8% on the nucleotide level, whereas representatives of the fifth lineage, including the new "subtype", differed from those of the other lineages by up to 21.3%.[9] Consequently, the fifth genetic lineage was reclassified as a virus, Ravn virus (RAVV), distinct from the virus represented by the four more closely related lineages, Marburg virus (MARV).[1]
Virus inclusion criteria
A virus that fulfills the criteria for being a member of the species
Disease
RAVV is one of two marburgviruses that causes Marburg virus disease (MVD) in humans (in the literature also often referred to as Marburg hemorrhagic fever, MHF). MVD due to RAVV infection cannot be differentiated from MVD caused by MARV by clinical observation alone, which is why the clinical presentation and pathology of infections by all marburgviruses is presented together on a separate page (see Marburg virus disease (MVD)). [citation needed]In the past, RAVV has caused the following MVD outbreaks:
| Year | Geographic location | Human cases/deaths (case-fatality rate) |
| 1987 | Kenya | 1/1 (100%)[8] |
| 1998–2000 | Durba and Watsa, Democratic Republic of the Congo
|
? (A total of 154 cases and 128 deaths of marburgvirus infection were recorded during this outbreak. The case fatality was 83%. Two different marburgviruses, RAVV and Marburg virus (MARV), cocirculated and caused disease. It has never been published how many cases and deaths were due to RAVV or MARV infection)[10][11][12] |
| 2007 | Uganda | 0/1 (0%)[13][14] |
Ecology
In 2009, the successful isolation of infectious RAVV was reported from caught healthy Egyptian rousettes (Rousettus aegyptiacus).[13] This isolation, together with the isolation of infectious MARV, strongly suggests that Old World fruit bats are involved in the natural maintenance of marburgviruses.[13]
References
- ^ PMID 21046175.
- ^ Spickler, Anna. "Ebolavirus and Marburgvirus Infections" (PDF).
- ^ US Animal and Plant Health Inspection Service (APHIS) and US Centers for Disease Control and Prevention (CDC). "National Select Agent Registry (NSAR)". Retrieved 2011-10-16.
- ^ US Department of Health and Human Services. "Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th Edition". Retrieved 2011-10-16.
- ^ US National Institutes of Health (NIH), US National Institute of Allergy and Infectious Diseases (NIAID). "Biodefense - NIAID Category A, B, and C Priority Pathogens". Retrieved 2011-10-16.
- ^ US Centers for Disease Control and Prevention (CDC). "Bioterrorism Agents/Diseases". Archived from the original on 2014-07-22. Retrieved 2011-10-16.
- ^ The Australia Group. "List of Biological Agents for Export Control". Archived from the original on 2011-08-06. Retrieved 2011-10-16.
- ^ )
- PMID 16775337.
- PMID 10546197.
- PMID 14720391.
- PMID 16943403. Archived from the original(PDF) on 2022-12-29. Retrieved 2018-12-31.
- ^ PMID 19649327.
- PMID 21987753.
Further reading
- Klenk, Hans-Dieter (1999), Marburg and Ebola Viruses. Current Topics in Microbiology and Immunology, vol. 235, Berlin, Germany: Springer-Verlag, ISBN 978-3-540-64729-4
- Klenk, Hans-Dieter; Feldmann, Heinz (2004), Ebola and Marburg Viruses - Molecular and Cellular Biology, Wymondham, Norfolk, UK: Horizon Bioscience, ISBN 978-0-9545232-3-7
- Kuhn, Jens H. (2008), Filoviruses - A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies. Archives of Virology Supplement, vol. 20, Vienna, Austria: SpringerWienNewYork, ISBN 978-3-211-20670-6
- Martini, G. A.; Siegert, R. (1971). Marburg Virus Disease. Berlin, Germany: Springer-Verlag. ISBN 978-0-387-05199-4.
- Ryabchikova, Elena I.; Price, Barbara B. (2004), Ebola and Marburg Viruses - A View of Infection Using Electron Microscopy, Columbus, Ohio, USA: Battelle Press, ISBN 978-1-57477-131-2