Renal cortical necrosis
Renal cortical necrosis | |
---|---|
Other names | Diffuse bilateral renal cortical necrosis (BRCN), diffuse cortical necrosis, acute cortical necrosis, acute kidney failure with acute cortical necrosis |
Specialty | Nephrology |
Renal cortical necrosis (RCN) is a rare cause of acute
Causes
Adults
- Pregnancy related (>50% of cases)
- Placental abruption
- Infected abortion
- Prolonged intrauterine fetal death
- Severe eclampsia
- HIV[2]
- Snake bites[3]
- Binge drinking[4]
- Shock
- Trauma
- Sickle cell disease[5]
- Systemic lupus erythematosus (SLE)[6]
- Sepsis[7]
- SLE-associated antiphospholipid syndrome[8]
- Vitamin deficiency[9]
- Pancreatitis[10]
- Malaria[11]
- Meningococcemia[12]
- Drug-induced toxicity (e.g. ATRA[14])
Babies
- Congenital heart disease
- Fetal-maternal transfusion
- Dehydration
- Perinatal asphyxia
- Anemia
- Placental hemorrhage
- Severe hemolytic disease
- Sepsis[7]
Pathophysiology
The exact pathologic mechanism for RCN is unclear, however the onset of small vessel pathology is likely an important aspect in the cause of this condition. In general the renal cortex is under greater oxygen tension and more prone to ischemic injury, especially at the level of the proximal collecting tubule, leading to its preferential damage in a sudden drop in perfusion. Rapidly corrected acute renal ischemia leads to acute tubular necrosis, from which complete recovery is possible, while more prolonged ischemia may lead to RCN. Pathologically, the cortex of the kidney is grossly atrophied with relative preservation of the gross structure of the medulla. The damage is usually bilateral owing to its underlying systemic causes, and is most frequently associated with pregnancy (>50% of cases).[1] It accounts for 2% of all cases of acute kidney failure in adults and more than 20% of cases of acute kidney failure during late pregnancy.[15][16]
Diagnosis
While the only diagnostic "gold standard" mechanism of diagnosis en vivo is via kidney biopsy, the clinical conditions and
Treatment
Patients will require dialysis to compensate for the function of their kidneys.
Prognosis
Cortical necrosis is a severe and life-threatening condition, with mortality rates over 50%.[citation needed] Those mortality rates are even higher in neonates with the condition due to the overall difficult nature of neonatal care and an increased frequency of comorbid conditions. The extent of the necrosis is a major determinant of the prognosis, which in turn is dependent on the duration of ischemia, duration of oliguria, and the severity of the precipitating conditions. Of those that survive the initial event, there are varying degrees of recovery possible, depending on the extent of the damage.
References
- ^ a b Deverajan, Prasad (May 26, 2011). Langman, Craig B (ed.). "eMedicine: Renal Cortical Necrosis". Medscape. Retrieved 27 March 2012.
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