Renato Dulbecco

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Renato Dulbecco
Born(1914-02-22)February 22, 1914
Catanzaro, Italy
DiedFebruary 19, 2012(2012-02-19) (aged 97)
NationalityItalian, American[3]
Alma materUniversity of Turin
Known forReverse transcriptase
Awards
Scientific career
Fields
Virologist
Institutions
Doctoral studentsHoward Temin[2]

Renato Dulbecco (

virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect animal cells.[7][8][9][10][11][12][13][14] He studied at the University of Turin under Giuseppe Levi, along with fellow students Salvador Luria and Rita Levi-Montalcini
, who also moved to the U.S. with him and won Nobel prizes. He was drafted into the Italian army in World War II, but later joined the resistance.

Early life

Dulbecco was born in

Italy), but spent his childhood and grew up in Liguria, in the coastal city Imperia. He graduated from high school at 16, then moved to the University of Turin. Despite a strong interest in mathematics and physics, he decided to study medicine. At only 22, he graduated in morbid anatomy and pathology under the supervision of professor Giuseppe Levi. During these years he met Salvador Luria and Rita Levi-Montalcini, whose friendship and encouragement would later bring him to the United States. In 1936 he was called up for military service as a medical officer, and later (1938) discharged. In 1940 Italy entered World War II and Dulbecco was recalled and sent to the front in France and Russia, where he was wounded. After hospitalization and the collapse of Fascism, he joined the resistance against the German occupation.[13]

Career and research

After the war he resumed his work at Levi's

tumour viruses and the genetic material of the cell." Temin and Baltimore arrived at the discovery of reverse transcriptase simultaneously and independently from each other; although Dulbecco did not take direct part in either of their experiments, he had taught the two methods they used to make the discovery.[18]

Throughout this time he also worked with

Salk Institute and then in 1972 to The Imperial Cancer Research Fund (now named the Cancer Research UK London Research Institute) where he was first appointed associate professor and then full professor.[19] Like many Italian scientists, Dulbecco did not have a PhD because it did not exist in the Italian higher education system (until it was introduced in 1980[20]). In 1986 he was among the scientists who launched the Human Genome Project.[21][22] From 1993 to 1997 he moved back to Italy, where he was president of the Institute of Biomedical Technologies at C.N.R. (National Council of Research) in Milan. He also retained his position on the faculty of Salk Institute for Biological Studies. Dulbecco was actively involved in research into identification and characterization of mammary gland cancer stem cells until December 2011.[23] His research using a stem cell model system suggested that a single malignant cell with stem cell properties may be sufficient to induce cancer in mice and can generate distinct populations of tumor-initiating cells also with cancer stem cell properties.[24]
Dulbecco's examinations into the origin of mammary gland cancer stem cells in solid tumors was a continuation of his early investigations of cancer being a disease of acquired mutations. His interest in cancer stem cells was strongly influenced by evidence that in addition to genomic mutations, epigenetic modification of a cell may contribute to the development or progression of cancer.

Nobel Prize

Dulbecco and his group demonstrated that the infection of normal cells with certain types of viruses (oncoviruses) led to the incorporation of virus-derived genes into the host-cell genome, and that this event lead to the transformation (the acquisition of a tumor phenotype) of those cells. As demonstrated by Temin and Baltimore, who shared the Nobel Prize with Dulbecco, the transfer of viral genes to the cell is mediated by an enzyme called reverse transcriptase (or, more precisely, RNA-dependent DNA polymerase), which replicates the viral genome (in this case made of RNA) into DNA, which is later incorporated in the host genome.

Oncoviruses are the cause of some forms of human

highly-active antiretroviral therapy
drug cocktail that is in contemporary use.

Other awards

In 1965 he received the

Foreign Member of the Royal Society (ForMemRS) in 1974.[1] In 1993, he was elected to the American Philosophical Society.[27]

References

  1. ^ a b "Fellowship of the Royal Society 1660-2015". London: Royal Society. Archived from the original on 2015-10-15.
  2. PMID 11615362
    .
  3. ^ Dulbecco is a naturalized American citizen. See Dulbécco, Renato in www.treccani.it
  4. ^ "Dulbecco". The American Heritage Dictionary of the English Language (5th ed.). HarperCollins. Retrieved 28 August 2019.
  5. ^ "Dulbecco". Collins English Dictionary. HarperCollins. Retrieved 28 August 2019.
  6. ^ Gellene, Denise (February 20, 2012). "Renato Dulbecco, 97, Dies; Won Prize for Cancer Study". New York Times. Retrieved March 29, 2014.
  7. ^ "The Nobel Prize in Physiology or Medicine 1975". Nobelprize.org. 12 Sep 2012
  8. PMID 22437605
    .
  9. .
  10. .
  11. .
  12. .
  13. ^ a b Nobel autobiography of Dulbecco
  14. ^ Renato Dulbecco telling his story at Web of Stories
  15. PMID 16589172
    .
  16. .
  17. .
  18. ^ Judson, Horace (2003-10-20). "No Nobel Prize for Whining". New York Times. Retrieved 2007-08-03.
  19. ^ "The Nobel Prize in Physiology or Medicine 1975".
  20. ^ "Dottorato, Enciclopedia Treeccani".
  21. PMID 3945817
    .
  22. .
  23. .
  24. .
  25. ^ "Renato Dulbecco". American Academy of Arts & Sciences. Retrieved 2022-03-16.
  26. ^ "Selman A. Waksman Award in Microbiology". National Academy of Sciences. Archived from the original on 12 January 2011. Retrieved 15 February 2011.
  27. ^ "APS Member History". search.amphilsoc.org. Retrieved 2022-03-16.

External links