Retinoid X receptor

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The retinoid X receptor (RXR)

9-cis retinoic acid, which is discussed controversially to be of endogenous relevance,[2][3] and 9-cis-13,14-dihydroretinoic acid, which is likely to be the major endogenous mammalian RXR-selective agonist.[4]

In a novel review publication, this 9-cis-13,14-dihydroretinoic acid was shown to be a metabolite not originating from the known

provitamin A (provitamin A1)).[5]

An independent pathway for generating this endogenous RXR-ligand 9-cis-13,14-dihydroretinoic acid from 9-cis-13,14-dihydroretinol present in food source and named vitamin A5 or alternatively via

cobalamin / vitamin B12
.

There are three retinoic X receptors (RXR): RXR-alpha, RXR-beta, and RXR-gamma, encoded by the RXRA, RXRB, RXRG genes, respectively.

RXR heterodimerizes with subfamily 1 nuclear receptors including CAR, FXR, LXR, PPAR,[6] PXR, RAR, TR, and VDR.

As with other

mRNA and eventually protein
.

See also

References

  1. S2CID 1476000
    .
  2. S2CID 269196
    .
  3. PMID 8380496
    .
  4. PMID 26030625
    .
  5. ^
    PMID 30358857
    .
  6. PMID 21493923
    .

External links
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