Retinoid X receptor alpha
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| Location (UCSC) | Chr 9: 134.32 – 134.44 Mb | Chr 2: 27.57 – 27.65 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene.[5]
Function
PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the cytochrome P450 system genes.[7]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".
Interactions
Retinoid X receptor alpha has been shown to
interact
with:
- BCL3,[8]
- BRD8,[9]
- CLOCK,[10]
- FXR[11]
- IGFBP3,[12]
- ITGB3BP,[13]
- LXR-β,[11]
- MyoD,[14]
- NCOA6,[15][16][17][18]
- NFKBIB,[19]
- NPAS2,[10]
- NRIP1,[20][21]
- NR4A1,[22]
- NCOA2,[23]
- NCOA3,[24]
- POU2F1,[25][26]
- PPARGC1A,[27]
- PPAR-γ,[28][29][30]
- RNF8,[31]
- RAR-α,[32][33]
- SHP,[34][35]
- TADA3L,[36]
- TBP,[37]
- TRIM24,[38][39]
- TR-β,[40][41] and
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186350 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015846 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 4232833.
- ^ "Entrez Gene: RXRA retinoid X receptor, alpha".
- ^ "Retinoic acid receptor RXR-alpha - Homo sapiens (Human)". UniProt.
- PMID 9812988.
- S2CID 25098867.
- ^ S2CID 6251321.
- ^ PMID 7760852.
- PMID 10874028.
- PMID 10490654.
- S2CID 6667231.
- PMID 10567404.
- PMID 11158331.
- S2CID 29349615.
- PMID 11773444.
- PMID 9452433.
- PMID 12549917.
- PMID 8887632.
- S2CID 17808479.
- ^ PMID 11514567.
- S2CID 15284825.
- PMID 10480874.
- PMID 10383413.
- PMID 11714715.
- PMID 7838715.
- S2CID 20343538.
- PMID 10882139.
- PMID 14981089.
- PMID 12052862.
- PMID 1314167.
- PMID 10594021.
- PMID 12198243.
- PMID 12235159.
- PMID 7667283.
- PMID 9115274.
- PMID 11851396.
- PMID 9368056.
- PMID 9171239.
- PMID 9632709.
Further reading
- Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L (December 2004). "Retinoid X receptors: X-ploring their (patho)physiological functions". Cell Death Differ. 11 (Suppl 2): S126–43. PMID 15608692.
- Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C (January 1992). "9-cis retinoic acid is a high affinity ligand for the retinoid X receptor". Cell. 68 (2): 397–406. S2CID 39338234.
- Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM (January 1992). "Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling". Nature. 355 (6359): 446–9. PMID 1310351.
- Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (February 1992). "Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1448–52. PMID 1311101.
- Bugge TH, Pohl J, Lonnoy O, Stunnenberg HG (April 1992). "RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors". EMBO J. 11 (4): 1409–18. PMID 1314167.
- Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (September 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Mol. Endocrinol. 6 (9): 1468–78. S2CID 24291055.
- Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM (August 1991). "A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR". Cell. 66 (3): 555–61. S2CID 13444623.
- Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM (May 1990). "Nuclear receptor that identifies a novel retinoic acid response pathway". Nature. 345 (6272): 224–9. S2CID 4232833.
- Oñate SA, Tsai SY, S2CID 28749162.
- Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature. 377 (6548): 454–7. S2CID 4361329.
- Schulman IG, Chakravarti D, Juguilon H, Romo A, Evans RM (August 1995). "Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation". Proc. Natl. Acad. Sci. U.S.A. 92 (18): 8288–92. PMID 7667283.
- Perlmann T, Jansson L (April 1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1". Genes Dev. 9 (7): 769–82. PMID 7705655.
- Rastinejad F, Perlmann T, Evans RM, Sigler PB (1995). "Structural determinants of nuclear receptor assembly on DNA direct repeats". Nature. 375 (6528): 203–11. S2CID 4373097.
- Forman BM, Umesono K, Chen J, Evans RM (1995). "Unique response pathways are established by allosteric interactions among nuclear hormone receptors". Cell. 81 (4): 541–50. S2CID 3203590.
- Seol W, Choi HS, Moore DD (1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Mol. Endocrinol. 9 (1): 72–85. PMID 7760852.
- Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D (June 1995). "Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha". Nature. 375 (6530): 377–82. S2CID 4371873.
- Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (February 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol. Endocrinol. 9 (2): 243–54. PMID 7776974.
- Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM (December 1994). "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha". Nucleic Acids Res. 22 (25): 5628–34. PMID 7838715.
- Lee JW, Ryan F, Swaffield JC, Johnston SA, Moore DD (March 1995). "Interaction of thyroid-hormone receptor with a conserved transcriptional mediator". Nature. 374 (6517): 91–4. S2CID 4324595.
- Lee MS, Sem DS, Kliewer SA, Provencal J, Evans RM, Wright PE (September 1994). "NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix". Eur. J. Biochem. 224 (2): 639–50. PMID 7925381.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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