Richard Lewontin

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Richard Lewontin
Lewontin's Fallacy
Not in Our Genes
The Dialectical Biologist
Spandrel (biology)
AwardsSewall Wright Award (1994)
Crafoord Prize (2015)
Thomas Hunt Morgan Medal (2017)
Scientific career
FieldsGenetics
Evolutionary biology
Population genetics
InstitutionsHarvard University
North Carolina State University
University of Rochester
University of Chicago
Columbia University
ThesisThe Effects of Population Density and Composition on Viability in Drosophila melanogaster (1955)
Doctoral advisorTheodosius Dobzhansky[1]
Doctoral studentsAdriana Briscoe
Jerry Coyne
Joseph Felsenstein
Martin Kreitman[2]
Russell Lande

Richard Charles Lewontin (March 29, 1929 – July 4, 2021

mathematical basis of population genetics and evolutionary theory, he applied techniques from molecular biology, such as gel electrophoresis, to questions of genetic variation
and evolution.

In a pair of seminal 1966 papers co-authored with

evolutionary theory
. From 1973 to 1998, he held an endowed chair in zoology and biology at Harvard University, and from 2003 until his death in 2021 he was a research professor there.

From a sociological perspective, Lewontin strongly opposed

genetic determinism[6]
and neodarwinism as expressed in the fields of sociobiology and evolutionary psychology.

Previously, as a member of

GMOs
by the "genetic-industrial complex".

Early life and education

Lewontin was born in New York City to parents descended from late 19th-century

École Libre des Hautes Études in New York. In 1951 he graduated from Harvard College with a BS degree in biology. In 1952, Lewontin received an MS degree in mathematical statistics, followed by a PhD degree in zoology in 1954,[8] both from Columbia University, where he was a student of Theodosius Dobzhansky
.

He held faculty positions at North Carolina State University, the University of Rochester, and the University of Chicago. In 1973 Lewontin was appointed as Alexander Agassiz Professor of Zoology and Professor of Biology at Harvard University, holding the position until 1998.

Career

Work in population genetics

Lewontin worked in both theoretical and experimental population genetics. A hallmark of his work was an interest in new technology. In 1960, he and Ken-Ichi Kojima gave the equations for change of haplotype frequencies with interacting natural selection at two loci.[9] Their paper gave a theoretical derivation of the equilibria expected, and also investigated the dynamics of the model by computer iteration. Lewontin later introduced the D' measure of linkage disequilibrium.[10]

In 1966, he and

heterozygous. (Harry Harris reported similar results for humans at about the same time.)[11]
Previous work with gel electrophoresis had been reports of variation in single loci and did not give any sense of how common variation was.

Lewontin and Hubby's paper also discussed the possible explanation of the high levels of variability by either balancing selection or neutral mutation. Martin Kreitman was later to do a pioneering survey of population-level variability in DNA sequences while a Ph.D. student in Lewontin's lab.[12]

Work on human genetic diversity

In a landmark paper published in 1972, Lewontin identified that most of the variation (80–85%) within human populations is found within local geographic groups, and differences attributable to the "

racial misclassification of an individual based on variation in a single genetic locus is approximately 30%, but the misclassification probability becomes close to zero if enough loci are studied.[14] That is, it appears that a majority of genetic variation is found within groups only if a single locus is used, but the reverse is true if analyzing a multiplicity of loci. Edwards' paper was commented on by Jonathan Marks, who argued that "the point of the theory of race was to discover large clusters of people that are principally homogeneous within and heterogeneous between, contrasting groups. Lewontin's analysis shows that such groups do not exist in the human species, and Edwards' critique does not contradict that interpretation."[15][16][17]

Affiliations

As of 2003, Lewontin was the Alexander Agassiz Research Professor at Harvard. He has worked with and had great influence on many philosophers of biology, including William C. Wimsatt, Elliott Sober, Philip Kitcher, Elisabeth Lloyd, Peter Godfrey-Smith, Sahotra Sarkar, and Robert Brandon, often inviting them to work in his lab.

Since 2013, Lewontin has been listed on the Advisory Council of the National Center for Science Education.[18]

Debates within mainstream evolutionary biology

In 1975, when

E. O. Wilson's book Sociobiology proposed evolutionary explanations for human social behaviors, biologists including Lewontin, his Harvard colleagues Stephen Jay Gould and Ruth Hubbard responded negatively. Robert Trivers called these accusations "coming from eminent biologists" "intellectually weak and lazy".[19]

Lewontin and Gould introduced the term

The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme." "Spandrels" were described as features of an organism that exist as a necessary consequence of other (perhaps adaptive) features, but do not directly improve fitness (and thus are not necessarily adaptive).[20]
The relative frequency of spandrels versus adaptations continues to stir controversy in evolutionary biology.

Lewontin was an early proponent of a hierarchy of

levels of selection in his article, "The Units of Selection". He has been a major influence on philosophers of biology, notably William C. Wimsatt (who taught with Lewontin and Richard Levins at the University of Chicago), Robert Brandon and Elisabeth Lloyd (who studied with Lewontin as graduate students), Philip Kitcher, Elliott Sober, and Sahotra Sarkar. Lewontin briefly argued for the historical nature of biological causality in "Is Nature Probable or Capricious?".[21]

In "Organism and Environment" in Scientia, and in more popular form in the last chapter of Biology as Ideology, Lewontin argued that while traditional Darwinism has portrayed the organism as a passive recipient of environmental influences, a correct understanding should emphasize the organism as an active constructor of its own environment. Niches are not pre-formed, empty receptacles into which organisms are inserted, but are defined and created by organisms. The organism-environment relationship is reciprocal and dialectical. M. W. Feldman and others[22] have developed Lewontin's conception in more detailed models under the term niche construction.

In the adaptationist view of evolution, the organism is a function of both the organism and environment, while the environment is only a function of itself. The environment is seen as autonomous and unshaped by the organism. Lewontin instead believed in a constructivist view, in which the organism is a function of the organism and environment, with the environment being a function of the organism and environment as well. This means that the organism shapes the environment as the environment shapes the organism. The organism shapes the environment for future generations.[23]

Lewontin criticized traditional neo-Darwinian approaches to adaptation. In his article "Adaptation" in the Italian Enciclopedia Einaudi, and in a modified version for Scientific American, he emphasized the need to give an engineering characterization of adaptation separate from measurement of number of offspring, rather than simply assuming organs or organisms are at adaptive optima.[24] Lewontin said that his more general, technical criticism of adaptationism grew out of his recognition that the fallacies of sociobiology reflect fundamentally flawed assumptions of adaptiveness of all traits in much of the modern evolutionary synthesis.

Lewontin accused neo-Darwinists of telling Just-So Stories when they try to show how natural selection explains such novelties as long-necked giraffes.[25]

Sociobiology and evolutionary psychology

Along with others, such as Gould, Lewontin was a persistent critic of some themes in

genetic determinism. In his writing, Lewontin suggests a more nuanced view of evolution is needed, which requires a more careful understanding of the context of the whole organism as well as the environment.[26]

Such concerns about what he viewed as the oversimplification of genetics led Lewontin to be a frequent participant in debates, and an active life as a public intellectual. He lectured widely to promote his views on evolutionary biology and science. In the book

IQ tests.[citation needed
]

Some academics have criticized him for rejecting

Marxist, and asserted that his philosophical views have bolstered his scientific work (Levins
and Lewontin 1985).

Agribusiness

Lewontin has written on the economics of agribusiness. He has contended that hybrid corn was developed and propagated not because of its superior quality, but because it allowed agribusiness corporations to force farmers to buy new seed each year rather than plant seed produced by their previous crop of corn (Lewontin 1982). Lewontin testified in an unsuccessful suit in California challenging the state's financing of research to develop automatic tomato pickers. This favored the profits of agribusiness over the employment of farm workers (Lewontin 2000).

Personal life

As of mid-2015, Lewontin and his wife Mary Jane (Christianson) lived on a farm in

Brattleboro, Vermont. They had four sons. He was an atheist.[27]

Lewontin died at his home in Cambridge, Massachusetts on July 4, 2021, at the age of 92.[3][28]

Recognition

Bibliography

Scholia has a profile for Richard Lewontin (Q659265).

References

  1. ^ Richard Lewontin at the Mathematics Genealogy Project
  2. ProQuest 303271509
    .
  3. ^ a b Angier, Natalie (July 7, 2021). "Richard C. Lewontin, Eminent Geneticist With a Sharp Pen, Dies at 92". The New York Times. Retrieved July 8, 2021.
  4. ^
    PMID 5968643
    .
  5. PMID 5968642
    .
  6. ISBN 978-0-415-94249-2
    .
  7. ^ Langer, Emily (July 16, 2021). "Geneticist Warned Against 'Genomania'". Washington Post. Vol. 144, no. 223. p. B6. Retrieved July 17, 2021.
  8. ProQuest 301991815
    .
  9. ^ Lewontin, R. C.; Kojima, Kenichi (1960). "The evolutionary dynamics of complex polymorphisms". Evolution 14: 458-472.
  10. ^ Lewontin, R. C. (1964). "The interaction of selection and linkage. I. General considerations; heterotic models". Genetics 49: 49-67.
  11. S2CID 43582403
    .
  12. S2CID 4348580
    .
  13. S2CID 21095796
    .
  14. PMID 12879450
    .
  15. ISBN 9781139789004
    .
  16. S2CID 52825769
    .
  17. ISBN 978-1351810777
    .
  18. ^ "Advisory Council". ncse.com. National Center for Science Education. Archived from the original on August 10, 2013. Retrieved October 30, 2018.
  19. ^ Elizabeth Allen et al., 1975, "Against 'Sociobiology'", The New York Review of Books, November 13, 1975
  20. S2CID 2129408
    .
  21. JSTOR 1293548
    .
  22. ^ Niche Construction: The Neglected Process in Evolution Odling-Smee F. J., Laland K. N., Feldman M. W. Princeton University Press, 2003
  23. ^ Richard Levins and Richard Lewontin, The Dialectical Biologist, 1985
  24. PMID 705323
    .
  25. ^ "Science Contra Darwin", Newsweek, April 8, 1985, p.50
  26. ISBN 0-394-50817-3
    .
  27. ^ "The Wars Over Evolution" New York Review of Books October 20, 2005 "I, his student and scientific epigone, ingested my unwavering atheism..."
  28. ^ "Richard Lewontin: Pioneering evolutionary biologist dies aged 92". New Scientist. July 5, 2021. Retrieved July 5, 2021.
  29. ^ "Scientist as Activist". globetrotter.berkeley.edu. Institute of International Studies. Archived from the original on August 11, 2004. Retrieved October 31, 2018.
  30. United States National Academy of Sciences
    . Retrieved April 3, 2022.
  31. Eurekalert. Archived from the original
    on March 24, 2017. Retrieved October 31, 2018.

Further reading

External links

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