Ro64-6198

Source: Wikipedia, the free encyclopedia.
Ro64-6198
Clinical data
Other namesRo64-6198
Identifiers
  • 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JSmol)
  • C1C[C@H]2CC[C@@H](C3=CC=CC(=C23)C1)N4CCC5(CC4)C(=O)NCN5C6=CC=CC=C6
  • InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1 ☒N
  • Key:JLFMYEAXZNPWBK-REWPJTCUSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Ro64-6198 is an opioid drug used in scientific research. It acts as a potent and selective agonist for the

antitussive effects,[7] and reduces the rewarding and analgesic effects of morphine, although it did not prevent the development of dependence.[8][9][10] It has been shown to reduce alcohol self-administration in animals and suppressed relapses in animal models of alcoholism, and ORL-1 agonists may have application in the treatment of alcoholism.[11]

Ro64-6198 was able to be recognised as a discriminative stimulus by rats distinct from other opioid receptor ligands,

respiratory depression or reinforcing effects.[15]

References