Rufinamide

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Rufinamide
Clinical data
Trade namesBanzel, Inovelon
AHFS/Drugs.comMonograph
MedlinePlusa609001
License data
Pregnancy
category
  • AU: B3
Routes of
administration
By mouth
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • UK: POM (Prescription only)
  • US: ℞-only[2]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability85% (under fed conditions); tmax = 4–6 hours
Protein binding34%
MetabolismCarboxylesterase-mediated hydrolysis (CYP not involved)
MetabolitesInactive
Elimination half-life6–10 hours
ExcretionUrine (85%)[2]
Identifiers
  • 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
JSmol)
  • O=C(c1nnn(c1)Cc2c(F)cccc2F)N
  • InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17) checkY
  • Key:POGQSBRIGCQNEG-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Rufinamide is an

Eisai
.

Rufinamide was approved by the US

generic medication.[7]

The

voltage-gated sodium channels,[8][9] a common target for antiepileptic drugs.[10] A recent study indicates subtle effects on the voltage-dependence of gating and the time course of inactivation in some sodium channel isoforms that could reduce neuronal excitability.[11]
However, this action cannot explain the unique spectrum of activity of rufinamide.

References

  1. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
  2. ^ a b "Banzel- rufinamide tablet, film coated Banzel- rufinamide suspension". DailyMed. 15 April 2020. Retrieved 21 October 2020.
  3. S2CID 19522242
    .
  4. .
  5. ^ FDA press release - FDA Approves New Drug to Treat Severe Form of Epilepsy
  6. ^ "European Public Assessment Report for rufinamide (INOVELON)". Archived from the original on 14 March 2009. Retrieved 25 November 2008.
  7. ^ "2022 First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
  8. PMID 16621450
    .
  9. .
  10. .
  11. .

External links

  • "Rufinamide". Drug Information Portal. U.S. National Library of Medicine.