Rufinamide
Clinical data | |
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Trade names | Banzel, Inovelon |
AHFS/Drugs.com | Monograph |
MedlinePlus | a609001 |
License data |
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Pregnancy category |
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Routes of administration | By mouth |
ATC code | |
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Legal status | |
Pharmacokinetic data | |
Bioavailability | 85% (under fed conditions); tmax = 4–6 hours |
Protein binding | 34% |
Metabolism | Carboxylesterase-mediated hydrolysis (CYP not involved) |
Metabolites | Inactive |
Elimination half-life | 6–10 hours |
Excretion | Urine (85%)[2] |
Identifiers | |
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JSmol) | |
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(what is this?) (verify) |
Rufinamide is an
Eisai
.
Rufinamide was approved by the US
generic medication.[7]
The
voltage-gated sodium channels,[8][9] a common target for antiepileptic drugs.[10] A recent study indicates subtle effects on the voltage-dependence of gating and the time course of inactivation in some sodium channel isoforms that could reduce neuronal excitability.[11]
However, this action cannot explain the unique spectrum of activity of rufinamide.
References
- ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
- ^ a b "Banzel- rufinamide tablet, film coated Banzel- rufinamide suspension". DailyMed. 15 April 2020. Retrieved 21 October 2020.
- S2CID 19522242.
- S2CID 38485532.
- ^ FDA press release - FDA Approves New Drug to Treat Severe Form of Epilepsy
- ^ "European Public Assessment Report for rufinamide (INOVELON)". Archived from the original on 14 March 2009. Retrieved 25 November 2008.
- ^ "2022 First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
- PMID 16621450.
- PMID 29313492.
- S2CID 2201038.
- PMID 24635129.
External links
- "Rufinamide". Drug Information Portal. U.S. National Library of Medicine.