Ruthenium red

Source: Wikipedia, the free encyclopedia.
Ammoniated ruthenium oxychloride
Identifiers
3D model (
JSmol
)
ChEMBL
ChemSpider
ECHA InfoCard
 100.228.922 Edit this at Wikidata
UNII
  • InChI=1S/6ClH.14H3N.2H2O.3Ru/h6*1H;14*1H3;2*1H2;;;/q;;;;;;;;;;;;;;;;;;;;;;+4;2*+5/p-6 checkY
    Key: CIBHIQPXTCXIRW-UHFFFAOYSA-H checkY
  • InChI=1/6ClH.14H3N.2H2O.3Ru/h6*1H;14*1H3;2*1H2;;;/q;;;;;;;;;;;;;;;;;;;;;;+4;2*+5/p-6
    Key: CIBHIQPXTCXIRW-CYFPFDDLAK
  • [Ru+5].[Ru+5].[Ru+4].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].O.O.N.N.N.N.N.N.N.N.N.N.N.N.N.N
Properties
Cl6H42N14O2Ru3
Molar mass 786.34 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

The inorganic dye ammoniated

mucopolysaccharides
.

Ruthenium red (RR) has also been used as a pharmacological tool to study specific cellular mechanisms. Selectivity is a significant issue in such studies as RR is known to interact with many proteins.

myosin light-chain phosphatase, and Ca2+ binding proteins such as calmodulin. Ruthenium red displays nanomolar potency against several of its binding partners (e.g. TRPV4, ryanodine receptors,...). For example, it is a potent inhibitor of intracellular calcium release by ryanodine receptors (Kd ~20 nM).[6] As a TRPA1 blocker, it assists in reducing the airway inflammation caused by pepper spray
.

RR has been used on plant material since 1890 for staining

pectins, mucilages, and gums. RR is a stereoselective stain for pectic acid, insofar as the staining site occurs between each monomer unit and the next adjacent neighbor.[7]

References

  1. PMID 21671873
    .
  2. PMID 22711817
    .
  3. PMID 23345406
    .
  4. PMID 24336289
    .
  5. PMID 17074387
    .
  6. S2CID 86436194. Archived from the original
    on 2008-04-23. Retrieved 2006-10-22.
  7. ^ Mariani Colombo P, Rascio N. "Ruthenium red staining for electron microscopy of plant material". Journal of Ultrastructure Research Volume 60, Issue 2, August 1977, Pages 135–139
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