SIRPG
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Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.[3][4][5] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000089012 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11185750.
- PMID 16339511.
- ^ a b "Entrez Gene: SIRPG signal-regulatory protein gamma".
Further reading
- Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature. 386 (6621): 181–6. S2CID 4259314.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Brooke G, Holbrook JD, Brown MH, Barclay AN (2004). "Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family". J. Immunol. 173 (4): 2562–70. PMID 15294972.
- Piccio L, Vermi W, Boles KS, et al. (2006). "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation". Blood. 105 (6): 2421–7. PMID 15383453.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMID 16344560.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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