Sortilin 1
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 1: 109.31 – 109.4 Mb | Chr 3: 108.19 – 108.27 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Sortilin (SORT1) is a
Structure
Gene
The SORT1 gene resides on chromosome 1 at the band 1p13.3 and includes 23
Protein
Sortilin is a member of the Vps10p sorting receptor family.
Function
In humans, sortilin is expressed over a wide range of cell types and tissues such as the
Clinical significance
Given its function in facilitating
Clinical marker
In 2007, chromosome 1p13.3 was identified as a promising locus through a
Interactions
Sortilin has been shown to
Interactive Pathway Map
Sortilin participates in interactions within the trans-Golgi network vesicle budding and BDNF signaling pathways.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134243 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068747 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: SORT1 sortilin 1".
- ^ "BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-08-16.
- ^ PMID 24531479.
- ^ PMID 11331584.
- ^ PMID 23966466.
- ^ PMID 25593281.
- ^ S2CID 22361357.
- ^ S2CID 4343450.
- PMID 35104807.
- ^ PMID 26950419.
- ^ PMID 25871389.
- ^ PMID 27066187.
- ^ PMID 25748612.
- ^ "SORT1 - Sortilin precursor - Homo sapiens (Human) - SORT1 gene & protein". www.uniprot.org. Retrieved 2016-08-16.
- S2CID 205522786.
- ^ S2CID 28152980.
- PMID 24985322.
- PMID 29167428.
- PMID 26724530.
- PMID 21966426.
- ^ PMID 34784266.
- PMID 10085125.
- ^ PMID 18258592.
- S2CID 32754981.
- PMID 22538429.
- PMID 27312323.
- PMID 20816088.
- ^ PMID 24121631.
- PMID 23948893.
- PMID 25881907.
- PMID 27392867.
- ^ PMID 17634449.
- PMID 26343387.
- PMID 22125304.
- ^ PMID 27085161.
- ^ S2CID 21977507.
Further reading
- Vincent JP, Mazella J, Kitabgi P (July 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences. 20 (7): 302–309. PMID 10390649.
- Mazella J (January 2001). "Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?". Cellular Signalling. 13 (1): 1–6. PMID 11257441.
- Petersen CM, Nielsen MS, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen HH, et al. (February 1997). "Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography". The Journal of Biological Chemistry. 272 (6): 3599–3605. PMID 9013611.
- Lin BZ, Pilch PF, Kandror KV (September 1997). "Sortilin is a major protein component of Glut4-containing vesicles". The Journal of Biological Chemistry. 272 (39): 24145–24147. PMID 9305862.
- Tauris J, Ellgaard L, Jacobsen C, Nielsen MS, Madsen P, Thøgersen HC, et al. (June 1998). "The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin". FEBS Letters. 429 (1): 27–30. PMID 9657377.
- Mazella J, Zsürger N, Navarro V, Chabry J, Kaghad M, Caput D, et al. (October 1998). "The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor". The Journal of Biological Chemistry. 273 (41): 26273–26276. PMID 9756851.
- Munck Petersen C, Nielsen MS, Jacobsen C, Tauris J, Jacobsen L, Gliemann J, et al. (February 1999). "Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding". The EMBO Journal. 18 (3): 595–604. PMID 9927419.
- Nielsen MS, Jacobsen C, Olivecrona G, Gliemann J, Petersen CM (March 1999). "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase". The Journal of Biological Chemistry. 274 (13): 8832–8836. PMID 10085125.
- Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, et al. (May 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". The EMBO Journal. 20 (9): 2180–2190. PMID 11331584.
- Takatsu H, Katoh Y, Shiba Y, Nakayama K (July 2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains". The Journal of Biological Chemistry. 276 (30): 28541–28545. PMID 11390366.
- Hampe W, Rezgaoui M, Hermans-Borgmeyer I, Schaller HC (June 2001). "The genes for the human VPS10 domain-containing receptors are large and contain many small exons". Human Genetics. 108 (6): 529–536. S2CID 23375354.
- Shiba T, Takatsu H, Nogi T, Matsugaki N, Kawasaki M, Igarashi N, et al. (February 2002). "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1". Nature. 415 (6874): 937–941. S2CID 4395774.
- Maeda S, Nobukuni T, Shimo-Onoda K, Hayashi K, Yone K, Komiya S, Inoue I (October 2002). "Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization". Journal of Cellular Physiology. 193 (1): 73–79. S2CID 32754981.
- Martin S, Navarro V, Vincent JP, Mazella J (October 2002). "Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line". Gastroenterology. 123 (4): 1135–1143. PMID 12360476.
- Navarro V, Vincent JP, Mazella J (November 2002). "Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line". Biochemical and Biophysical Research Communications. 298 (5): 760–764. PMID 12419319.
- Martin S, Vincent JP, Mazella J (February 2003). "Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia". The Journal of Neuroscience. 23 (4): 1198–1205. PMID 12598608.
- Lefrancois S, Zeng J, Hassan AJ, Canuel M, Morales CR (December 2003). "The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin". The EMBO Journal. 22 (24): 6430–6437. PMID 14657016.